Vitamin E: a sensor and an information transducer of the cell oxidation state

Détails

ID Serval
serval:BIB_D9D0C126FAD4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Vitamin E: a sensor and an information transducer of the cell oxidation state
Périodique
American Journal of Clinical Nutrition
Auteur(s)
Azzi  A., Boscoboinik  D., Marilley  D., Ozer  N. K., Stauble  B., Tasinato  A.
ISSN
0002-9165 (Print)
Statut éditorial
Publié
Date de publication
12/1995
Volume
62
Numéro
6 Suppl
Pages
1337S-1346S
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
We studied the effects of RRR-alpha-tocopherol and RRR-beta-tocopherol in smooth muscle cells from rat (line A7r5) and human aortas. RRR-alpha-Tocopherol, but not RRR-beta-tocopherol, inhibited smooth muscle cell proliferation in a dose-dependent manner at concentrations in the range from 10 to 50 mumol/L. RRR-beta-Tocopherol added simultaneously with RRR-alpha-tocopherol prevented growth inhibition. The earliest event brought about by RRR-alpha-tocopherol in the signal transduction cascade controlling receptor-mediated cell growth was the activation of the transcription factor AP-1. RRR-beta-tocopherol alone was without effect but in combination with RRR-alpha-tocopherol prevented the AP-1 activating effect of the latter. Protein kinase C was inhibited by RRR-alpha-tocopherol and not by RRR-beta-tocopherol, which also in this case prevented the effect of RRR-alpha-tocopherol. Calyculin A, a protein phosphatase inhibitor, prevented the effect of RRR-alpha-tocopherol on protein kinase C. The data can be rationalized by a model in which a tocopherol-binding protein discriminates between RRR-alpha-tocopherol and RRR-beta-tocopherol and initiates a cascade of events at the level of cell signal transduction that leads to the inhibition of cell proliferation.
Mots-clé
Animals Base Sequence Cell Division/drug effects Cells, Cultured DNA/metabolism Humans Molecular Sequence Data Muscle, Smooth, Vascular/cytology/drug effects/metabolism Oxidation-Reduction Protein Kinase C/metabolism Rats Signal Transduction/drug effects Transcription Factor AP-1/metabolism Vitamin E/*pharmacology
Pubmed
Web of science
Création de la notice
29/01/2008 9:44
Dernière modification de la notice
03/03/2018 21:53
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