Ex vivo detectable human CD8 T-cell responses to cancer-testis antigens.

Détails

Ressource 1Télécharger: BIB_D9CFEA5BF1AA.P001.pdf (311.50 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_D9CFEA5BF1AA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Ex vivo detectable human CD8 T-cell responses to cancer-testis antigens.
Périodique
Cancer Research
Auteur(s)
Baumgaertner P., Rufer N., Devevre E., Derre L., Rimoldi D., Geldhof C., Voelter V., Liénard D., Romero P., Speiser D.E.
ISSN
0008-5472 (Print)
ISSN-L
0008-5472
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
66
Numéro
4
Pages
1912-1916
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish. PDF type: Priority Report
Résumé
Clinical trials have shown that strong tumor antigen-specific CD8 T-cell responses are difficult to induce but can be achieved for T-cells specific for melanoma differentiation antigens, upon repetitive vaccination with stable emulsions prepared with synthetic peptides and incomplete Freund's adjuvant. Here, we show in four melanoma patients that ex vivo detectable T-cells and thus strong T-cell responses can also be induced against the more universal cancer-testis antigens NY-ESO-1 and Mage-A10. Interestingly, all patients had ex vivo detectable T-cell responses against multiple antigens after serial vaccinations with three peptides emulsified in incomplete Freund's adjuvant. Antigen-specific T-cells displayed an activated phenotype and secreted IFNgamma. The robust immune responses provide a solid basis for further development of human T-cell vaccination.
Mots-clé
Antigens, Neoplasm/immunology, CD8-Positive T-Lymphocytes/immunology, Cancer Vaccines/adverse effects, Cancer Vaccines/immunology, Cell Differentiation/immunology, Cross Reactions, Epitopes, T-Lymphocyte/immunology, HLA-A2 Antigen/immunology, Humans, Immunologic Memory, Lymphocyte Activation, MART-1 Antigen, Melanoma/immunology, Melanoma/therapy, Membrane Proteins/immunology, Neoplasm Proteins/immunology, Skin Neoplasms/immunology, Skin Neoplasms/therapy
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:28
Dernière modification de la notice
09/05/2019 2:02
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