Neuropeptide Y: the universal soldier.

Détails

ID Serval
serval:BIB_D9BD60B2868E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Neuropeptide Y: the universal soldier.
Périodique
Cellular and Molecular Life Sciences
Auteur(s)
Pedrazzini T., Pralong F., Grouzmann E.
ISSN
1420-682X
Statut éditorial
Publié
Date de publication
02/2003
Peer-reviewed
Oui
Volume
60
Numéro
2
Pages
350-377
Langue
anglais
Notes
Publication types: Journal Article ; Review - Publication Status: ppublish
Résumé
The peptidic neuropeptide Y (NPY) has received great attention because it has been implicated in the regulation of several organ systems. In particular, NPY is involved in the regulatory loops that control food intake in the hypothalamus and appears also to be important for regulating the activity of neuroendocrine axes under poor metabolic conditions. Furthermore, NPY exerts vasoconstrictive action on the vasculature and potentiates the actions of many other vasoconstrictors. In addition, it was demonstrated to have trophic properties and could therefore contribute to cardiovascular remodeling. These various effects plus a number of others make NPY an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure.
Mots-clé
Animals, Antihypertensive Agents/therapeutic use, Appetite Stimulants/therapeutic use, Cardiovascular Diseases/drug therapy, Cardiovascular System/metabolism, Forecasting, Humans, Hypothalamus/metabolism, Models, Biological, Neuropeptide Y/metabolism, Neuropeptide Y/therapeutic use, Neurosecretory Systems/metabolism, Protein Processing, Post-Translational, Receptors, Neuropeptide Y/genetics, Receptors, Neuropeptide Y/metabolism, Signal Transduction
Pubmed
Web of science
Création de la notice
25/01/2008 9:45
Dernière modification de la notice
03/03/2018 21:53
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