Long synthetic peptides for the production of vaccines and drugs: a technological platform coming of age.

Détails

ID Serval
serval:BIB_D9BBF6510985
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Long synthetic peptides for the production of vaccines and drugs: a technological platform coming of age.
Périodique
Science Translational Medicine
Auteur(s)
Corradin G., Kajava A.V., Verdini A.
ISSN
1946-6242 (Electronic)
ISSN-L
1946-6234
Statut éditorial
Publié
Date de publication
2010
Volume
2
Numéro
50
Pages
50rv3
Langue
anglais
Résumé
Long synthetic peptides (LSPs) have a variety of important clinical uses as synthetic vaccines and drugs. Techniques for peptide synthesis were revolutionized in the 1960s and 1980s, after which efficient techniques for purification and characterization of the product were developed. These improved techniques allowed the stepwise synthesis of increasingly longer products at a faster rate, greater purity, and lower cost for clinical use. A synthetic peptide approach, coupled with bioinformatics analysis of genomes, can tremendously expand the search for clinically relevant products. In this Review, we discuss efforts to develop a malaria vaccine from LSPs, among other clinically directed work.
Mots-clé
Computational Biology/methods, Genomics/methods, Malaria Vaccines/chemistry, Peptides/chemical synthesis, Peptides/chemistry, Vaccines/chemistry
Pubmed
Web of science
Création de la notice
02/02/2011 11:58
Dernière modification de la notice
03/03/2018 21:53
Données d'usage