Systems biology in the development of HIV vaccines.

Détails

ID Serval
serval:BIB_D9A012FB0528
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Systems biology in the development of HIV vaccines.
Périodique
Current Opinion In Hiv and Aids
Auteur(s)
Haddad E.K., Pantaleo G.
ISSN
1746-6318 (Electronic)
ISSN-L
1746-630X
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
7
Numéro
1
Pages
44-49
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
PURPOSE OF REVIEW: In the present review, we will provide the scientific rationale for applying systems biology to the development of vaccines and particularly HIV vaccines, the predictive power of systems biology on the vaccine immunological profile, the correlation between systems biology and the immunological functional profiles of different candidate vaccines, and the value of systems biology in the selection process of identifying the best-in-class candidate vaccines and in the decision process to move into in-vivo evaluation in clinical trials.
RECENT FINDINGS: Systems biology has been recently applied to the characterization of the protective yellow fever vaccine YF17D and of seasonal flu vaccines. This has been instrumental in the identification of the components of the immune response that need to be stimulated by the vaccine in order to generate protective immunity. It is worth noting that a systems biology approach is currently being performed to identify correlates of immune protection of the RV144 Thai vaccine, the only known vaccine that showed modest protection against HIV reacquisition.
SUMMARY: Systems biology represents a novel and powerful approach to predict the vaccine immunological profile, to identify the protective components of the immune response, and to help in the selection process of the best-in-class vaccines to move into clinical development.
Mots-clé
AIDS Vaccines/immunology, Biological Markers, Drug Discovery/methods, HIV/immunology, Humans, Systems Biology/methods
Pubmed
Web of science
Création de la notice
25/09/2012 17:48
Dernière modification de la notice
03/03/2018 21:53
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