Antidote treatment for cyanide poisoning with hydroxocobalamin causes bright pink discolouration and chemical-analytical interferences.

Détails

ID Serval
serval:BIB_D957915C6196
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Antidote treatment for cyanide poisoning with hydroxocobalamin causes bright pink discolouration and chemical-analytical interferences.
Périodique
Forensic Science International
Auteur(s)
Brunel C., Widmer C., Augsburger M., Dussy F., Fracasso T.
ISSN
1872-6283 (Electronic)
ISSN-L
0379-0738
Statut éditorial
Publié
Date de publication
2012
Volume
223
Numéro
1-3
Pages
e10-e12
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Here we report the case of a 70-year-old woman who committed suicide by cyanide poisoning. During resuscitation cares, she underwent an antidote treatment by hydroxocobalamin. Postmortem investigations showed marked bright pink discolouration of organs and fluids, and a lethal cyanide blood concentration of 43 mg/L was detected by toxicological investigation. Discolouration of hypostasis and organs has widely been studied in forensic literature. In our case, we interpreted the unusual pink coloration as the result of the presence of hydroxocobalamin. This substance is a known antidote against cyanide poisoning, indicated because of its efficiency and poor adverse effects. However, its main drawback is to interfere with measurements of many routine biochemical parameters. We have tested the potential influence of this molecule in some routine postmortem investigations. The results are discussed.
Mots-clé
Cyanide poisoning, Hydroxocobalamin, Antidote, Hypostasis discolouration, Bright pink discolouration
Pubmed
Web of science
Création de la notice
22/03/2013 15:49
Dernière modification de la notice
03/03/2018 21:52
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