Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus.

Détails

ID Serval
serval:BIB_D94F1D5EEBE5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus.
Périodique
Pediatric Transplantation
Auteur(s)
Anastaze Stelle K., Belli D.C., Parvex P., Girardin E., Giroud A., Wildhaber B., McLin V.A.
ISSN
1399-3046 (Electronic)
ISSN-L
1397-3142
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
16
Numéro
3
Pages
250-256
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
The aim of this study was to analyze the impact of TAC on medium term (three-yr follow-up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post-OLT (p = 0.003), with a trend toward significance between pre-OLT and 36 months (p = 0.17). There was no correlation between CrCl and TAC troughs (p = 0.783). Sixteen percent of patients had CrCl <60 mL/min/1.73 m(2) pre-OLT vs. none at 36 months post-OLT. TRP values were normal throughout the study. UPr/Cr decreased insignificantly over time and correlated significantly with TAC trough levels (p = 0.031). UCa/Cr values normalized by the third-month post-OLT, decreasing significantly over the time (p = 0.000) but did not correlate with TAC troughs. At three months post-OLT, 65.2% of patients needed antihypertensive therapy, and no patients needed more than one antihypertensive treatment after one yr. Despite nephrotoxic side effects in the early postoperative phase, this study shows that 65.5% patients had a normal renal function by three yr post-OLT. Tubular indices correlated with TAC trough levels.
Mots-clé
Adolescent, Antihypertensive Agents/pharmacology, Child, Child, Preschool, Chlorides/pharmacology, Chromium Compounds/pharmacology, Female, Humans, Immunosuppressive Agents/pharmacology, Infant, Kidney Glomerulus/drug effects, Kidney Glomerulus/pathology, Kidney Tubules/drug effects, Kidney Tubules/pathology, Liver/drug effects, Liver Transplantation/methods, Male, Retrospective Studies, Tacrolimus/pharmacology, Time Factors, Treatment Outcome
Pubmed
Web of science
Création de la notice
21/02/2015 12:58
Dernière modification de la notice
03/03/2018 21:52
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