Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus.
Details
Serval ID
serval:BIB_D94F1D5EEBE5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus.
Journal
Pediatric Transplantation
ISSN
1399-3046 (Electronic)
ISSN-L
1397-3142
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
16
Number
3
Pages
250-256
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
The aim of this study was to analyze the impact of TAC on medium term (three-yr follow-up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post-OLT (p = 0.003), with a trend toward significance between pre-OLT and 36 months (p = 0.17). There was no correlation between CrCl and TAC troughs (p = 0.783). Sixteen percent of patients had CrCl <60 mL/min/1.73 m(2) pre-OLT vs. none at 36 months post-OLT. TRP values were normal throughout the study. UPr/Cr decreased insignificantly over time and correlated significantly with TAC trough levels (p = 0.031). UCa/Cr values normalized by the third-month post-OLT, decreasing significantly over the time (p = 0.000) but did not correlate with TAC troughs. At three months post-OLT, 65.2% of patients needed antihypertensive therapy, and no patients needed more than one antihypertensive treatment after one yr. Despite nephrotoxic side effects in the early postoperative phase, this study shows that 65.5% patients had a normal renal function by three yr post-OLT. Tubular indices correlated with TAC trough levels.
Keywords
Adolescent, Antihypertensive Agents/pharmacology, Child, Child, Preschool, Chlorides/pharmacology, Chromium Compounds/pharmacology, Female, Humans, Immunosuppressive Agents/pharmacology, Infant, Kidney Glomerulus/drug effects, Kidney Glomerulus/pathology, Kidney Tubules/drug effects, Kidney Tubules/pathology, Liver/drug effects, Liver Transplantation/methods, Male, Retrospective Studies, Tacrolimus/pharmacology, Time Factors, Treatment Outcome
Pubmed
Web of science
Create date
21/02/2015 11:58
Last modification date
20/08/2019 15:58