Human inhalation exposure to iron oxide particles

Détails

ID Serval
serval:BIB_D91F54A24F3E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Human inhalation exposure to iron oxide particles
Périodique
BioNanoMaterials
Auteur(s)
Lewinski Nastassja, Graczyk Halshka, Riediker Michael
ISSN-L
2193-066X
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
14
Numéro
1-2
Pages
5-23
Langue
anglais
Notes
Le DOI est erroné sur le site de l'éditeur (De Gruyter)
Résumé
In the past decade, many studies have been conducted to determine the health effects induced by exposure to engineered nanomaterials (NMs). Specifically for exposure via inhalation, numerous in vitro and animal in vivo inhalation toxicity studies on several types of NMs have been published. However, these results are not easily extrapolated to judge the effects of inhaling NMs in humans, and few published studies on the human response to inhalation of NMs exist. Given the emergence of more industries utilizing iron oxide nanoparticles as well as more nanomedicine applications of superparamagnetic iron oxide nanoparticles (SPIONs), this review presents an overview of the inhalation studies that have been conducted in humans on iron oxides. Both occupational exposure studies on complex iron oxide dusts and fumes, as well as human clinical studies on aerosolized, micron-size iron oxide particles are discussed. Iron oxide particles have not been described to elicit acute inhalation response nor promote lung disease after chronic exposure. The few human clinical studies comparing inhalation of fine and ultrafine metal oxide particles report no acute changes in the health parameters measured. Taken together existing evidence suggests that controlled human exposure to iron oxide nanoparticles, such as SPIONs, could be conducted safely.
Mots-clé
Nanoparticles , Iron Compounds , Oxidative Stress , Lung , Inhalation Exposure , Occupational Health
Open Access
Oui
Création de la notice
03/10/2013 12:56
Dernière modification de la notice
09/05/2019 1:59
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