Neuropsychiatric symptoms in cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics.
Details
State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_D8FFCBBF9B53
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neuropsychiatric symptoms in cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics.
Journal
Journal of neurology, neurosurgery, and psychiatry
Working group(s)
Alzheimer's Disease Neuroimaging Initiative
Contributor(s)
Weiner M., Aisen P., Jack C.R., Jagust W., Landau S., Rivera-Mindt M., Okonkwo O., Shaw L.M., Lee E.B., Toga A.W., Beckett L., Harvey D., Green R.C., Saykin A.J., Nho K., Perrin R.J., Tosun D., Sachdev P., Drake E., Montine T., Conti C., Nosheny R., Sacrey D., Fockler J., Miller M.J., Kwang W., Jin C., Diaz A., Ashford M., Flenniken D., Kormos A., Rafii M., Raman R., Jimenez G., Donohue M., Salazar J., Fidell A., Boatwright V., Robison J., Zimmerman C., Cabrera Y., Walter S., Clanton T., Shaffer E., Webb C., Hergesheimer L., Smith S., Ogwang S., Mahboubi P., Pizzola J., Jenkins C., Beckett L., Harvey D., Donohue M., Saito N., Diaz A., Hussen K., Amaza H., Thao M., Parkins S., Ayo O., Glittenberg M., Hoang I., Germano K., Strong J., Weisensel T., Magana F., Thomas L., Guzman V., Ajayi A., Benedetto J., Talavera S., Felmlee J., Fox N.C., Thompson P., DeCarli C., Forghanian-Arani A., Borowski B., Reyes C., Hedberg C., Ward C., Schwarz C., Reyes D., Gunter J., Moore-Weiss J., Kantarci K., Matoush L., Senjem M., Vemuri P., Reid R., Malone I., Thomopoulos S.I., Nir T.M., Jahanshad N., Knaack A., Fletcher E., Harvey D., Tosun-Turgut D., Chen S., Choe M., Crawford K., Yushkevich P.A., Das S., Koepp R.A., Rabinovici G., Villemagne V., LoPresti B., Morris J., Franklin E., Bernhardt H., Cairns N.J., Taylor-Reinwald L., Lee E.B., Lee V.M., Korecka M., Brylska M., Wan Y., Trojanowki J.Q., Crawford K., Neu S., Foroud T.M., Jo T., Risacher S.L., Craft H., Apostolova L.G., Nudelman K., Faber K., Potter Z., Lacy K., Kaddurah-Daouk R., Shen L., Karlawish J., Erickson C., Grill J., Largent E., Harkins K., Thal L., Kachaturian Z., Frank R., Snyder P.J., Buckholtz N., Hsiao J.K., Ryan L., Molchan S., Carrillo M., Potter W., Barnes L., Bernard M., González H., Ho C., Hsiao J.K., Jackson J., Masliah E., Masterman D., Ryan L., Silverberg N., Silbert L., Kaye J., White S., Pierce A., Thomas A., Clay T., Schwartz D., Devereux G., Taylor J., Ryan J., Nguyen M., DeCapo M., Shang Y., Schneider L., Munoz C., Ferman D., Conant C., Martin K., Oleary K., Pawluczyk S., Trejo E., Dagerman K., Teodoro L., Becerra M., Fairooz M., Garrison S., Boudreau J., Avila Y., Brewer J., Jacobson A., Gama A., Kim C., Little E., Frascino J., Ferng N., Trujillo S., Heidebrink J., Koeppe R., MacDonald S., Malyarenko D., Ziolkowski J., O'Connor J., Robert N., Lowe S., Rogers V., Hackenmiller B., Boeve B., Albers C., Kreuger C., Jones D., Knopman D., Botha H., Magnuson J., Graff-Radford J., Crawley K., Schumacher M., McKinzie S., Smith S., Helland T., Lowe V., Ramanan V., Pavlik V., Faircloth J., Bishop J., Nath J., Chaudhary M., Kataki M., Yu M., Pacini N., Barker R., Brooks R., Aggarwal R., Honig L., Stern Y., Mintz A., Cordona J., Hernandez M., Long J., Arnold A., Groves A., Middleton A., Vogler B., McCurry C., Mayo C., Raji C., Amtashar F.S., Klemp H., Elmore H., Ruszkiewicz J., Kusuran J., Stewart J., Horenkamp J., Greeson J., Wever K., Vo K., Larkin K., Rao L., Schoolcraft L., Gallagher L., Paczynski M., McMillan M., Holt M., Gagliano N., Henson R., LaBarge R., Swarm R., Munie S., Cepeda S., Winterton S., Hegedus S., Wilson T., Harte T., Bonacorsi Z., Geldmacher D., Watkins A., Barger B., Smelser B., Bates C., Stover C., McKinley E., Ikner G., Hendrix H., Cooper H., Mahaffey J., Robbins L., Ashley L., Natelson-Love M., Carter P., Solomon V., Grossman H., Groome A., Ardolino A., Kaplan A., Sheppard F., Burgos-Rivera G., Garcia-Camilo G., Lim J., Neugroschl J., Jackson K., Evans K., Soleimani L., Sano M., Ghesani N., Binder S., Apuango X., Sood A., Troutman A., Blanchard K., Richards A., Nelson G., Hendrickson K., Yurko E., Plenge J., Rufo V., Shah R., Duara R., Lynch B., Chirinos C., Dittrich C., Campbell D., Mejia D., Perez G., Colvee H., Gonzalez J., Gondrez J., Knaack J., Acevedo M., Cereijo M., Greig-Cust M., Villar M., Wishnia M., Detling S., Barker W., Albert M., Moghekar A., Rodzon B., Demsky C., Pontone G., Pekar J., Farrington L., Pomper M., Johnson N., Alo T., Sadowski M., Ulysse A., Masurkar A., Marti B., Mossa D., Geesey E., Petrocca E., Schulze E., Wong J., Boonsiri J., Kenowsky S., Martinez T., Briglall V., Murali Doraiswamy P., Nwosu A., Adhikari A., Hellegers C., Petrella J., James O., Wong T., Hawk T., Vaishnavi S., McCoubrey H., Nasrallah I., Rovere R., Maneval J., Robinson E., Rivera F., Uffelman J., Combs M., O'Donnell P., Manning S., King R., Nieto A., Glueck A., Mandal A., Swain A., Gamble B., Meacham B., Forenback D., Ross D., Cheatham E., Hartman E., Cornell G., Harp J., Ashe L., Goins L., Watts L., Yazell M., Mandal P., Buckler R., Vincent S., Rudd T., Lopez O., Malia A., Chiado C., Zik C., Ruszkiewicz J., Savage K., Fenice L., Oakley M., Tacey P., Berman S., Bowser S., Hegedus S., Saganis X., Porsteinsson A., Mathewson A., Widman A., Holvey B., Clark E., Morales E., Young I., Ruszkiewicz J., Hopkins K., Martin K., Kowalski N., Hunt R., Calzavara R., Kurvach R., D'Ambrosio S., Thai G., Vides B., Lieb B., McAdams-Ortiz C., Toso C., Mares I., Moorlach K., Liu L., Corona M., Nguyen M., Tallakson M., McDonnell M., Rangel M., Basheer N., Place P., Romero R., Tam S., Nguyen T., Thomas A., Frolov A., Khera A., Browning A., Kelley B., Dawson C., Mathews D., Most E., Phillips E., Nguyen L., Nunez M., Miller M., Jones M.R., Martinez N., Logan R., McColl R., Pham S., Fox T., Moore T., Levey A., Brown A., Kippels A., Ellison A., Lyons C., Hales C., Parry C., Williams C., McCorkle E., Harris G., Rose H., Jooma I., Al-Amin J., Lah J., Webster J., Swiniarski J., Chapman L., Donnelly L., Mariotti L., Locke M., Vaughn P., Penn R., Carpentier S., Yeboah S., Basadre S., Malakauskas S., Lyron S., Villinger T., Burney T., Burns J., Abusalim A., Dahlgren A., Montero A., Arthur A., Dooly H., Kreszyn K., Berner K., Gillen L., Scanlan M., Madison M., Mathis N., Switzer P., Townley R., Fikru S., Sullivan S., Wright E., Beigi M., Daley A., Ko A., Luong B., Nyborg G., Morales J., Durbin K., Garcia L., Parand L., Macias L., Monserratt L., Farchi M., Wu P., Hernandez R., Rodriguez T., Graff-Radford N., Marolt A., Thomas A., Aloszka D., Moncayo E., Westerhold E., Day G., Chrestensen K., Imhansiemhonehi M., McKinzie S., Stephens S., Grant S., Brosch J., Perkins A., Saunders A., Kovac D., Polson H., Mwaura I., Mejia K., Britt K., King K., Nichols K., Lawrence K., Rankin L., Farlow M., Wiesenauer P., Bryant R., Herring S., Lynch S., Wilson S., Day T., Korst W., Dyck C., Mecca A., Miller A., Brennan A., Khan A., Ruan A., Gunnoud C., Mendonca C., Raynes-Goldfinger D., Salardini E., Hidalgo E., Cooper E., Singh E., Murphy E., May J., Stanhope J., Lam J., Waszak J., Nelsen K., Sacaza K., Hasbani M., Donahue M., Chen M.K., Barcelos N., Eigenberger P., Bonomi R., O'Dell R., Jefferson S., Khasnavis S., Smilowitz S., DeStefano S., Good S., Camarro T., Clayton V., Cavrel Y., Lu Y., Chertkow H., Bergman H., Hosein C., Black S., Kapadia A., Bhan A., Lam B., Scott C., Gabriel G., Bray J., Zotovic L., Gutierrez M., Masellis M., Farshadi M., Gui M., Mitchell M., Taylor R., Endre R., Taghi-Zada Z., Hsiung R., English C., Kim E., Yau E., Tong H., Barlow L., Jennings L., Assaly M., Nunes P., Marian T., Kertesz A., Rogers J., Trost D., Wint D., Bernick C., Munic D., Grant I., Korkoyah A., Raja A., Lapins A., Ryan C., Pejic J., Basham K., Lukose L., Haddad L., Quinlan L., Houghtaling N., Sadowsky C., Martinez W., Villena T., Reynolds B., Forero A., Ward C., Brennan E., Figueroa E., Esposito G., Mallory J., Johnson K., Turner K., Seidenberg K., McCann K., Bassett M., Chadwick M., Turner R., Bean R., Sharma S., Marshall G., Haviari A., Pietras A., Wallace B., Munro C., Rivera-Delpin G., Hustead H., Levesque I., Ramirez J., Nolan K., Glennon K., Palou M., Erkkinen M., DaSilva N., Friedman P., Silver R.M., Salazar R., Polleys R., McGinnis S., Gale S., Hall T., Luu T., Chao S., Lin E., Coleman J., Epperson K., Vasanawala M., Atri A., Rangel A., Evans B., Monarrez C., Cline C., Liebsack C., Bandy D., Goldfarb D., Intorcia D., Olgin J., Clark K., King K., York K., Reade M., Callan M., Glass M., Johnson M., Gutierrez M., Goddard M., Trncic N., Choudhury P., Reyes P., Lowery S., Hall S., Olgin S., Santiago S., Alosco M., Ton A., Jimenez A., Ellison A., Tran A., Anderson B., Carter D., Veronelli D., Lenio S., Steinberg E., Mez J., Weller J., Johns J., Harkins J., Hoti I., Mwicigi J., Schultz O., Lauture M., Denis R., Killiany R., Singh S., Lenio S., Qiu W., Devis Y., Obisesan T., Stone A., Ordor D., Udodong I., Okonkwo I., Khan J., Turner J., Hughes K., Kadiri O., Duffy C., Moss A., Stapleton K., Toth M., Sanders M., Ayres M., Hamski M., Fatica P., Ogrocki P., Ash S., Pot S., Chen D., Soto A., Tanase C., Bissig D., Vanya H., Russell H., Patel H., Zhang H., Wallace K., Ayers K., Gallegos M., Forloines M., Sinn M., Kahulugan Q., Isip R., Calderon S., Hamm T., Borrie M., Lee T.Y., Bartha R., Johnson S., Asthana S., Carlsson C.M., Perrin A., Tariot P., Fleisher A., Reeder S., Capote H., Emborsky A., Mattle A., Ajtai B., Wagner B., Myers B., Slazyk D., Fragale D., Fransen E., Macnamara H., Falletta J., Hirtreiter J., Mechtler L., King M., Asbach M., Rainka M., Zawislak R., Wisniewski S., O'Malley S., Jimenez-Knight T., Peehler T., Aladeen T., Bates V., Wenner V., Elmalik W., Scharre D.W., Ramamurthy A., Bouchachi S., Kataki M., Tarawneh R., Kelley B., Celmins D., Leader A., Figueroa C., Bauerle H., Patterson K., Reposa M., Presto S., Ahmed T., Stewart W., Pearlson G.D., Blank K., Anderson K., Santulli R.B., Schwartz E.S., Williamson J., Jessup A., Williams A., Duncan C., O'Connell A., Gagnon K., Zamora E., Bateman J., Crawford F., Thompson D., Walker E., Rowell J., White M., Ledford P., Bohlman S., Henkle S., Bottoms J., Moretz L., Hoover B., Shannon M., Rogers S., Baker W., Harrison W., Wu C.K., DeMarco A., Stipanovich A., Arcuri D., Clark J., Davis J., Doyon K., Amoyaw M., Acosta M., Bailey R., Warren S., Fogerty T., Sanborn V., Riddle M., Salloway S., Malloy P., Correia S., Windon C., Blackburn M., Rosen H.J., Miller B.L., Smith A., Mba I., Echevarria J., Janavs J., Roglaski E., Yong M., Devine R., Okhravi H., Rivera E., Kalowsky T., Smith C., Rosario C., Masdeu J., Le R., Gurung M., Sabbagh M., Garcia A., Slaughter M., Elayan N., Acothley S., Pomara N., Hernando R., Pomara V., Reichert C., Brawman-Mintzer O., Acree A., Williams A., Long C., Long R., Newhouse P., Hill S., Boegel A., Seshadri S., Saklad A., Jones F., Hu W., Sotelo V., Rojas Y., Mintzer J., Longmire C., Spicer K.
ISSN
1468-330X (Electronic)
ISSN-L
0022-3050
Publication state
Published
Issued date
24/03/2025
Peer-reviewed
Oui
Volume
96
Number
4
Pages
370-382
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Neuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer's disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This study aimed to identify plasma proteins that may serve as biomarkers for NPS and NPS-related clinical disease progression.
A panel of 190 plasma proteins was quantified using Luminex xMAP in the Alzheimer's Disease Neuroimaging Initiative cohort. NPS and cognitive performance were assessed at baseline and after 1 and 2 years. Logistic regression, receiver operating characteristic analysis and cross-validation were used to address the relations of interest.
A total of 507 participants with mild cognitive impairment (n=396) or mild AD dementia (n=111) were considered. Selected plasma proteins improved the prediction of NPS (area under the curve (AUC) from 0.61 to 0.76, p<0.001) and future NPS (AUC from 0.63 to 0.80, p<0.001) when added to a reference model. Distinct protein panels were identified for single symptoms. Among the selected proteins, ANGT, CCL1 and IL3 were associated with NPS at all three time points while CCL1, serum glutamic oxaloacetic transaminase and complement factor H were also associated with cognitive decline. The associations were independent of the presence of cerebral AD pathology as assessed using cerebrospinal fluid biomarkers.
Plasma proteins are associated with NPS and improve prediction of future NPS.
A panel of 190 plasma proteins was quantified using Luminex xMAP in the Alzheimer's Disease Neuroimaging Initiative cohort. NPS and cognitive performance were assessed at baseline and after 1 and 2 years. Logistic regression, receiver operating characteristic analysis and cross-validation were used to address the relations of interest.
A total of 507 participants with mild cognitive impairment (n=396) or mild AD dementia (n=111) were considered. Selected plasma proteins improved the prediction of NPS (area under the curve (AUC) from 0.61 to 0.76, p<0.001) and future NPS (AUC from 0.63 to 0.80, p<0.001) when added to a reference model. Distinct protein panels were identified for single symptoms. Among the selected proteins, ANGT, CCL1 and IL3 were associated with NPS at all three time points while CCL1, serum glutamic oxaloacetic transaminase and complement factor H were also associated with cognitive decline. The associations were independent of the presence of cerebral AD pathology as assessed using cerebrospinal fluid biomarkers.
Plasma proteins are associated with NPS and improve prediction of future NPS.
Keywords
Humans, Alzheimer Disease/blood, Biomarkers/blood, Biomarkers/cerebrospinal fluid, Male, Female, Cognitive Dysfunction/blood, Cognitive Dysfunction/cerebrospinal fluid, Aged, Proteomics, Disease Progression, Neuropsychological Tests, Aged, 80 and over, Blood Proteins/analysis, ALZHEIMER'S DISEASE, APATHY, BEHAVIOURAL DISORDER, DEPRESSION, MOLECULAR BIOLOGY
Pubmed
Web of science
Open Access
Yes
Create date
20/09/2024 16:07
Last modification date
29/03/2025 8:22