The gut microbiota influences skeletal muscle mass and function in mice.

Détails

ID Serval
serval:BIB_D8EEBE1CC953
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The gut microbiota influences skeletal muscle mass and function in mice.
Périodique
Science translational medicine
Auteur(s)
Lahiri S., Kim H., Garcia-Perez I., Reza M.M., Martin K.A., Kundu P., Cox L.M., Selkrig J., Posma J.M., Zhang H., Padmanabhan P., Moret C., Gulyás B., Blaser M.J., Auwerx J., Holmes E., Nicholson J., Wahli W., Pettersson S.
ISSN
1946-6242 (Electronic)
ISSN-L
1946-6234
Statut éditorial
Publié
Date de publication
24/07/2019
Peer-reviewed
Oui
Volume
11
Numéro
502
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free mice that had a gut microbiota. Compared to pathogen-free mouse skeletal muscle, germ-free mouse skeletal muscle showed atrophy, decreased expression of insulin-like growth factor 1, and reduced transcription of genes associated with skeletal muscle growth and mitochondrial function. Nuclear magnetic resonance spectrometry analysis of skeletal muscle, liver, and serum from germ-free mice revealed multiple changes in the amounts of amino acids, including glycine and alanine, compared to pathogen-free mice. Germ-free mice also showed reduced serum choline, the precursor of acetylcholine, the key neurotransmitter that signals between muscle and nerve at neuromuscular junctions. Reduced expression of genes encoding Rapsyn and Lrp4, two proteins important for neuromuscular junction assembly and function, was also observed in skeletal muscle from germ-free mice compared to pathogen-free mice. Transplanting the gut microbiota from pathogen-free mice into germ-free mice resulted in an increase in skeletal muscle mass, a reduction in muscle atrophy markers, improved oxidative metabolic capacity of the muscle, and elevated expression of the neuromuscular junction assembly genes Rapsyn and Lrp4 Treating germ-free mice with short-chain fatty acids (microbial metabolites) partly reversed skeletal muscle impairments. Our results suggest a role for the gut microbiota in regulating skeletal muscle mass and function in mice.
Pubmed
Création de la notice
06/08/2019 17:44
Dernière modification de la notice
21/08/2019 6:33
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