Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Allergologie: 2. Mastocytose systémique--nouvelles stratégies thérapeutiques [Systemic mastocytosis--new therapeutic strategies].
Revue Médicale Suisse
Publication types: English Abstract ; Journal Article ; ReviewPublication Status: ppublish
Systemic mastocytosis is characterized by an excessive proliferation of mast cells and their accumulation in different organs. Avoidance of trigger factors leading to anaphylaxis is a general measure valid for all forms of mastocytosis. A premedication is necessary in case of surgery, anesthesia or administration of radiocontrast agents. Symptomatic treatment comprises antihistamines, anti-leukotrienes, proton pump inhibitors and topical corticosteroids. Indolent mastocytosis with refractory symptoms, the rare cases of aggressive mastocytosis with organ dysfunction and the even rarer mast cell leukemia require cytoreductive therapy. First-line agents are interferon alpha 2b and imatinib, a tyrosine kinase inhibitor. To date there is no curative treatment.
Allergy and Immunology/trends, Anti-Inflammatory Agents/therapeutic use, Cladribine/therapeutic use, Humans, Interferon-alpha/therapeutic use, Mastocytosis, Systemic/diagnosis, Mastocytosis, Systemic/prevention & control, Medical Oncology/methods, Medical Oncology/trends, Protein Kinase Inhibitors/therapeutic use, Recombinant Proteins/therapeutic use, Therapies, Investigational/methods, Therapies, Investigational/trends
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