Chelating agents as coating molecules for iron oxide nanoparticles

Détails

ID Serval
serval:BIB_D8AFB4556EA5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Chelating agents as coating molecules for iron oxide nanoparticles
Périodique
RSC Advances
Auteur(s)
Bonvin Debora, Bastiaansen Jessica A. M., Stuber Matthias, Hofmann Heinrich, Mionić Ebersold Marijana
ISSN
2046-2069
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
7
Numéro
88
Pages
55598-55609
Langue
anglais
Résumé
Due to their high chemical affinity towards metal ions, chelating agents (CAs) have been used for decades for water purification, but also for protection against metal intoxication and in nanomedicine as linking molecules at the surface of nanoparticles. However, this strong chemical activity could also impact their colloidal behavior, which is essential for biomedical applications. Therefore, we coated iron oxide nanoparticles (IONPs) with four CAs, differing in their number of active chemical groups, with variations from 2 to 5 dents containing carboxylic groups: iminodiacetic acid (IDA), nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA). We found large differences between the CA-coated IONPs depending on the CA nature, especially regarding their agglomeration state and colloidal behavior, but also consequently their cellular uptake. Surprisingly, although CAs have been widely used for biomedical applications, CA-coated IONPs, especially IDA-and EDTA-coated IONPs, showed non-negligible toxicity. Moreover, for their application as contrast agents for MRI, we found that CA-coated IONPs displayed high r(2) relaxivities, which differed according to their agglomeration state. Overall, our study suggests that CAs, depending on their chemical nature, can induce agglomeration and toxicity, which could be harmful in a clinical setting.
Mots-clé
General Chemistry, General Chemical Engineering, General Chemistry, General Chemical Engineering
Web of science
Open Access
Oui
Création de la notice
03/01/2018 14:40
Dernière modification de la notice
09/05/2019 1:58
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