Risk factor profile and management of cerebrovascular patients in the REACH Registry.

Détails

ID Serval
serval:BIB_D8A5A011EF6A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Risk factor profile and management of cerebrovascular patients in the REACH Registry.
Périodique
Cerebrovascular Diseases
Auteur(s)
Röther J., Alberts M.J., Touzé E., Mas J.L., Hill M.D., Michel P., Bhatt D.L., Aichner F.T., Goto S., Matsumoto M., Ohman E.M., Okada Y., Uchiyama S., D'Agostino R., Hirsch A.T., Wilson P.W., Steg P.G.
Collaborateur(s)
REACH Registry Investigators
Contributeur(s)
Reid C., Aichner F., Wascher T., Laloux P., de Albuquerque DC. , Djorgova J., Cohen EA., Corbalan R., Chuanzhen LV., Tierala I., Mas JL., Cacoub P., Montalescot G., Parhofer K., Zeymer U., Röther J., Elisaf M., Lopez R., Chan J., Pfliegler G., Sutrisna B., Porath A., Ikeda Y., Khalil I., Babarskiene R., Zambahari R., Gaxiola E., Poldermans D., Abola MT., Gil V., Popa C., Belenkov Y., Panchenko E., Chamsi-Pasha H., Cheng YT., Dong-Joo O., Suarez C., Baumgartner I., Liau CS., Sritara P., Al Mahmeed W., Morrell J., Tseluyko V., Alberts M., Califf RM., Cannon CP., Eagle K., Hirsch AT.
ISSN
1421-9786 (Electronic)
ISSN-L
1015-9770
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
25
Numéro
4
Pages
366-374
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND: Cerebrovascular disease (CVD) is a global public health problem. CVD patients are at high risk of recurrent stroke and other atherothrombotic events. Prevalence of risk factors, comorbidities, utilization of secondary prevention therapies and adherence to guidelines all influence the recurrent event rate. We assessed these factors in 18,992 CVD patients within a worldwide registry of stable outpatients.
METHODS: The Reduction of Atherothrombosis for Continued Health Registry recruited >68,000 outpatients (44 countries). The subjects were mainly recruited by general practitioners (44%) and internists (29%) if they had symptomatic CVD, coronary artery disease, peripheral arterial disease (PAD) and/or >or=3 atherothrombotic risk factors.
RESULTS: The 18,992 CVD patients suffered a stroke (53.7%), transient ischemic attack (TIA) (27.7%) or both (18.5%); 40% had symptomatic atherothrombotic disease in >or=1 additional vascular beds: 36% coronary artery disease; 10% PAD and 6% both. The prevalence of risk factors at baseline was higher in the TIA subgroup than in the stroke group: treated hypertension (83.5/82.0%; p = 0.02), body mass index >or=30 (26.7/20.8%; p < 0.0001), hypercholesterolemia (65.1/52.1%; p < 0.0001), atrial fibrillation (14.7/11.9%; p < 0.0001) and carotid artery disease (42.3/29.7%; p < 0.0001). CVD patients received antiplatelet agents (81.7%), oral anticoagulants (17.3%), lipid-lowering agents (61.2%) and antihypertensives (87.9%), but guideline treatment targets were frequently not achieved (54.5% had elevated blood pressure at baseline, while 4.5% had untreated diabetes).
CONCLUSIONS: A high percentage of CVD patients have additional atherothrombotic disease manifestations. The risk profile puts CVD patients, especially the TIA subgroup, at high risk for future atherothrombotic events. Undertreatment is common worldwide and adherence to guidelines needs to be enforced.
Mots-clé
Aged, Anticoagulants/therapeutic use, Cerebrovascular Disorders/drug therapy, Cerebrovascular Disorders/epidemiology, Female, Guidelines as Topic, Humans, Hypercholesterolemia/epidemiology, Hypertension/epidemiology, Intracranial Arteriosclerosis/drug therapy, Intracranial Arteriosclerosis/epidemiology, Ischemic Attack, Transient/drug therapy, Ischemic Attack, Transient/epidemiology, Male, Middle Aged, Platelet Aggregation Inhibitors/therapeutic use, Prevalence, Prospective Studies, Recurrence/prevention & control, Registries/statistics & numerical data, Risk Factors, Stroke/drug therapy, Stroke/epidemiology, World Health
Pubmed
Web of science
Création de la notice
13/10/2009 12:05
Dernière modification de la notice
03/03/2018 21:51
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