Secretory IgA, a major immunoglobulin in most bovine external secretions.

Détails

ID Serval
serval:BIB_D8637A28DD65
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Secretory IgA, a major immunoglobulin in most bovine external secretions.
Périodique
Journal of Immunology
Auteur(s)
Mach J.P., Pahud J.J.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
1971
Volume
106
Numéro
2
Pages
552-563
Langue
anglais
Résumé
Bovine secretory IgA (SIgA), recently identified in colostrum, was shown to be homologous to human SIgA by immunologic cross-reaction. A quantitative study indicated that bovine SIgA, a minor component of colostrum, is a major immunoglobulin in most other external secretions including saliva, spermatic fluid, lacrimal, nasal and gastrointestinal secretions. SIgA was isolated from saliva. The free form of secretory component was found to be abundant in milk. A normal lactating cow produces about 1.2 g of this protein per day. Two forms of IgA were identified in serum: a normal serum IgA with no secretory antigenic determinant, and a small amount of SIgA. In vitro synthesis of SIgA by the salivary gland was studied by tissue cultures with incorporation of labeled amino acids.
Mots-clé
Animals, Antigens/analysis, Autoradiography, Carbon Isotopes, Cattle, Chromatography, Colostrum/immunology, Epitopes
Pubmed
Web of science
Création de la notice
24/04/2013 10:27
Dernière modification de la notice
03/03/2018 21:50
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