IL-12-mediated STAT4 signaling and TCR signal strength cooperate in the induction of CD40L in human and mouse CD8(+) T cells.

Détails

ID Serval
serval:BIB_D851A49AA57E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
IL-12-mediated STAT4 signaling and TCR signal strength cooperate in the induction of CD40L in human and mouse CD8(+) T cells.
Périodique
European Journal of Immunology
Auteur(s)
Stark R., Hartung A., Zehn D., Frentsch M., Thiel A.
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
43
Numéro
6
Pages
1511-1517
Langue
anglais
Notes
Publication types: Journal Article
Résumé
CD40L is one of the key molecules bridging the activation of specific T cells and the maturation of professional and nonprofessional antigen-presenting cells including B cells. CD4(+) T cells have been regarded as the major T-cell subset that expresses CD40L upon cognate activation; however, we demonstrate here that a putative CD8(+) helper T-cell subset expressing CD40L is induced in human and murine CD8(+) T cells in vitro and in mice immunized with antigen-pulsed dendritic cells. IL-12 and STAT4-mediated signaling was the major instructive cytokine signal boosting the ability of CD8(+) T cells to express CD40L both in vitro and in vivo. Additionally, TCR signaling strength modulated CD40L expression in CD8(+) T cells after primary differentiation in vitro as well as in vivo. The induction of CD40L in CD8(+) T cells regulated by IL-12 and TCR signaling may enable CD8(+) T cells to respond autonomously of CD4(+) T cells. Thus, we propose that under proinflammatory conditions, a self-sustaining positive feedback loop could facilitate the efficient priming of T cells stimulated by high affinity peptide displaying APCs.
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/08/2013 9:49
Dernière modification de la notice
09/05/2019 1:57
Données d'usage