The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends.
Details
Serval ID
serval:BIB_D80BD276A7D5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends.
Journal
Ocular immunology and inflammation
ISSN
1744-5078 (Electronic)
ISSN-L
0927-3948
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
27
Number
3
Pages
465-473
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Abstract
Purpose: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. Methods: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included. Results: 59 (6.13%) of COTS-1 underwent PCR analysis. PCR was positive for Mycobacterium TB in 33 patients (23 males; all Asian Indians). 26 patients were PCR negative (18 males). Eight patients with negative PCR had systemic TB. Anti-TB therapy was given in 18 negative and 31 PCR cases. At 1-year follow-up, five patients with positive PCR (15.15%) and three with negative PCR (11.54%) had persistence/worsening of inflammation. Conclusions: Data from COTS-1 suggest that PCR is not commonly done for diagnosing intraocular TB and positive/negative results may not influence management or treatment outcomes in the real world scenario.
Keywords
Adolescent, Adult, Aged, Antitubercular Agents/therapeutic use, Aqueous Humor/microbiology, Child, DNA, Bacterial/analysis, Eye Infections, Bacterial/diagnosis, Eye Infections, Bacterial/drug therapy, Eye Infections, Bacterial/microbiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mycobacterium tuberculosis/genetics, Mycobacterium tuberculosis/isolation & purification, Polymerase Chain Reaction/methods, Retrospective Studies, Tuberculosis, Ocular/diagnosis, Tuberculosis, Ocular/drug therapy, Tuberculosis, Ocular/microbiology, Uveitis/diagnosis, Uveitis/drug therapy, Uveitis/microbiology, Young Adult, Anti-tubercular therapy, choroidal tuberculoma, choroiditis, polymerase chain reaction, tuberculosis
Pubmed
Web of science
Create date
10/01/2018 9:17
Last modification date
05/08/2020 6:26