Article: article from journal or magazin.
Severe post-EBV encephalopathy associated with myelin oligodendrocyte glycoprotein-specific immune response.
Journal of Neuroimmunology
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. However, we found a potent MOG-specific cellular and humoral immune response. Interestingly, MOG-specific cellular immune response rapidly decreased, paralleling the improvement of clinical condition. In conclusion, this detailed study shows that acute EBV infection can trigger a potent auto-inflammatory response in the CNS, without evidence of an overt infection.
Adult, Antibodies/metabolism, Brain Diseases/blood, Brain Diseases/cerebrospinal fluid, Cell Proliferation, Disease Progression, Enzyme-Linked Immunosorbent Assay/methods, Epstein-Barr Virus Infections/blood, Epstein-Barr Virus Infections/cerebrospinal fluid, Herpesvirus 4, Human/metabolism, Humans, Interferon-gamma/metabolism, Male, Myelin Basic Proteins/metabolism, Myelin-Associated Glycoprotein/immunology
Web of science
Last modification date