Severe post-EBV encephalopathy associated with myelin oligodendrocyte glycoprotein-specific immune response.

Détails

ID Serval
serval:BIB_D78D489A8FDD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Severe post-EBV encephalopathy associated with myelin oligodendrocyte glycoprotein-specific immune response.
Périodique
Journal of Neuroimmunology
Auteur(s)
Jilek S., Kuhle J., Meylan P., Reichhart M.D., Pantaleo G., Du Pasquier R.A.
ISSN
0165-5728[print], 0165-5728[linking]
Statut éditorial
Publié
Date de publication
10/2007
Peer-reviewed
Oui
Volume
192
Numéro
1-2
Pages
192-197
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. However, we found a potent MOG-specific cellular and humoral immune response. Interestingly, MOG-specific cellular immune response rapidly decreased, paralleling the improvement of clinical condition. In conclusion, this detailed study shows that acute EBV infection can trigger a potent auto-inflammatory response in the CNS, without evidence of an overt infection.
Mots-clé
Adult, Antibodies/metabolism, Brain Diseases/blood, Brain Diseases/cerebrospinal fluid, Cell Proliferation, Disease Progression, Enzyme-Linked Immunosorbent Assay/methods, Epstein-Barr Virus Infections/blood, Epstein-Barr Virus Infections/cerebrospinal fluid, Herpesvirus 4, Human/metabolism, Humans, Interferon-gamma/metabolism, Male, Myelin Basic Proteins/metabolism, Myelin-Associated Glycoprotein/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 15:56
Dernière modification de la notice
20/08/2019 16:57
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