Maintenance therapy for CTCL: importance for prevention of disease progression.
Details
Serval ID
serval:BIB_D7743F1FF0D8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Maintenance therapy for CTCL: importance for prevention of disease progression.
Journal
Leukemia & lymphoma
ISSN
1029-2403 (Electronic)
ISSN-L
1026-8022
Publication state
Published
Issued date
12/2024
Peer-reviewed
Oui
Volume
65
Number
12
Pages
1883-1890
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Abstract
There are no established maintenance protocols for cutaneous lymphomas. We aim to determine patient treatments and outcomes during the COVID-19 pandemic in order to uncover the most effective maintenance protocols for cutaneous lymphomas and impact of treatment interruption. Data was collected retrospectively from nine international institutions, including 149 patients. Younger patients had earlier stages of disease and were most frequently treated with skin-directed therapies including topical steroids, mechlorethamine gel, and phototherapy. Treatment interruption varied by treatment type and stage, with patients on topical therapies and earlier stages of disease being least likely to experience interruption. Treatment interruption was significantly associated with progression of disease and worse outcomes, with twice as many patients progressing who had interruption compared to those without interruption. This study may demonstrate the significance of continuous maintenance therapies, even in younger patients with early stages of disease.
Keywords
Humans, Disease Progression, Female, Male, Middle Aged, Retrospective Studies, Aged, Adult, Lymphoma, T-Cell, Cutaneous/therapy, Lymphoma, T-Cell, Cutaneous/pathology, COVID-19/prevention & control, COVID-19/epidemiology, Maintenance Chemotherapy/methods, Aged, 80 and over, Skin Neoplasms/therapy, Skin Neoplasms/pathology, Skin Neoplasms/prevention & control, Treatment Outcome, SARS-CoV-2, Phototherapy/methods, Mechlorethamine/administration & dosage, Mechlorethamine/therapeutic use, Neoplasm Staging, CTCL, Maintenance therapy, covid-19, cutaneous lymphoma, early-stage, treatments
Pubmed
Web of science
Create date
12/07/2024 12:15
Last modification date
03/12/2024 7:07