Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo.

Détails

Ressource 1Télécharger: s00294-017-0748-x.pdf (635.07 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_D761E6C388AC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo.
Périodique
Current Genetics
Auteur(s)
Tamás M.J., Fauvet B., Christen P., Goloubinoff P.
ISSN
1432-0983 (Electronic)
ISSN-L
0172-8083
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
64
Numéro
1
Pages
177-181
Langue
anglais
Résumé
Cadmium is a highly poisonous metal and a human carcinogen, but the molecular mechanisms underlying its cellular toxicity are not fully understood. Recent findings in yeast cells indicate that cadmium exerts its deleterious effects by inducing widespread misfolding and aggregation of nascent proteins. Here, we discuss this novel mode of toxic heavy metal action and propose a mechanism by which molecular chaperones may reduce the damaging effects of heavy metal ions on protein structures.

Mots-clé
Cadmium, Metal toxicity, Molecular chaperones, Protein aggregation, Protein folding, Saccharomyces cerevisiae
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/03/2018 9:04
Dernière modification de la notice
20/08/2019 15:57
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