Diffusion-weighted imaging in acute demyelinating myelopathy.

Details

Serval ID
serval:BIB_D73066CEAECB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Diffusion-weighted imaging in acute demyelinating myelopathy.
Journal
Neuroradiology
Author(s)
Zecca C., Cereda C., Wetzel S., Tschuor S., Staedler C., Santini F., Nadarajah N., Bassetti C.L., Gobbi C.
ISSN
1432-1920 (Electronic)
ISSN-L
0028-3940
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
54
Number
6
Pages
573-578
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
INTRODUCTION: Diffusion-weighted imaging (DWI) has become a reference MRI technique for the evaluation of neurological disorders. Few publications have investigated the application of DWI for inflammatory demyelinating lesions. The purpose of the study was to describe diffusion-weighted imaging characteristics of acute, spinal demyelinating lesions.
METHODS: Six consecutive patients (two males, four females; aged 28-64 years) with acute spinal cord demyelinating lesions were studied in a prospective case series design from June 2009 to October 2010. We performed magnetic resonance imaging studies from 2 to 14 days from symptom onset on the patients with relapsing remitting multiple sclerosis (n = 3) or clinically isolated syndrome (n = 3). Main outcome measures were diffusion-weighted imaging and apparent diffusion coefficient pattern (ADC) of acute spinal cord demyelinating lesions.
RESULTS: All spinal lesions showed a restricted diffusion pattern (DWI+/ADC-) with a 24% median ADC signal decrease. A good correlation between clinical presentation and lesion site was observed.
CONCLUSION: Acute demyelinating spinal cord lesions show a uniform restricted diffusion pattern. Clinicians and neuro-radiologists should be aware that this pattern is not necessarily confirmatory for an ischaemic aetiology.
Keywords
Acute Disease, Adult, Demyelinating Diseases/pathology, Diffusion Magnetic Resonance Imaging/methods, Female, Humans, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Spinal Cord/pathology, Spinal Cord Diseases/pathology
Pubmed
Create date
17/03/2016 9:13
Last modification date
20/08/2019 15:56
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