Role of cell cycle regulators in adipose tissue and whole body energy homeostasis.

Détails

ID Serval
serval:BIB_D70173D2EEC9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Role of cell cycle regulators in adipose tissue and whole body energy homeostasis.
Périodique
Cellular and molecular life sciences
Auteur(s)
Lopez-Mejia I.C., Castillo-Armengol J., Lagarrigue S., Fajas L.
ISSN
1420-9071 (Electronic)
ISSN-L
1420-682X
Statut éditorial
Publié
Date de publication
03/2018
Peer-reviewed
Oui
Volume
75
Numéro
6
Pages
975-987
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
In the course of the last decades, metabolism research has demonstrated that adipose tissue is not an inactive tissue. Rather, adipocytes are key actors of whole body energy homeostasis. Numerous novel regulators of adipose tissue differentiation and function have been identified. With the constant increase of obesity and associated disorders, the interest in adipose tissue function alterations in the XXIst century has become of paramount importance. Recent data suggest that adipocyte differentiation, adipose tissue browning and mitochondrial function, lipogenesis and lipolysis are strongly modulated by the cell division machinery. This review will focus on the function of cell cycle regulators in adipocyte differentiation, adipose tissue function and whole body energy homeostasis; with particular attention in mouse studies.
Mots-clé
Adipose Tissue/metabolism, Animals, Cell Cycle Checkpoints, Cell Cycle Proteins/genetics, Cell Cycle Proteins/metabolism, Cyclin-Dependent Kinase Inhibitor Proteins/genetics, Cyclin-Dependent Kinase Inhibitor Proteins/metabolism, Cyclin-Dependent Kinases/genetics, Cyclin-Dependent Kinases/metabolism, Cyclins/genetics, Cyclins/metabolism, E2F Transcription Factors/genetics, E2F Transcription Factors/metabolism, Energy Metabolism, Humans, Adipose tissue, CDKs, Cell cycle, Cyclins, Insulin resistance, Metabolism, Obesity
Pubmed
Web of science
Création de la notice
19/10/2017 15:18
Dernière modification de la notice
19/11/2018 7:26
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