Article: article from journal or magazin.
CD8+ T cell development: CD4 to the rescue.
News and Views
How immature CD4+CD8+ thymocytes become committed to either the CD4 (helper) or CD8 (cytotoxic) lineage is controversial. Genetic ablation of a silencer element in the gene encoding CD4 provides new evidence that CD8 lineage commitment occurs via a stochastic, rather than instructive, mechanism.
Animals, Antigens, CD4/genetics, Antigens, CD4/metabolism, Cell Lineage, Gene Silencing, Mice, Models, Immunological, Regulatory Sequences, Nucleic Acid, Stochastic Processes, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Helper-Inducer/immunology, Thymus Gland/immunology
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