CD8+ T cell development: CD4 to the rescue.
Details
Serval ID
serval:BIB_D6E291A0A03B
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
CD8+ T cell development: CD4 to the rescue.
Journal
Nature Immunology
ISSN
1529-2908 (Print)
ISSN-L
1529-2908
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
2
Number
12
Pages
1091-1092
Language
english
Notes
News and Views
Abstract
How immature CD4+CD8+ thymocytes become committed to either the CD4 (helper) or CD8 (cytotoxic) lineage is controversial. Genetic ablation of a silencer element in the gene encoding CD4 provides new evidence that CD8 lineage commitment occurs via a stochastic, rather than instructive, mechanism.
Keywords
Animals, Antigens, CD4/genetics, Antigens, CD4/metabolism, Cell Lineage, Gene Silencing, Mice, Models, Immunological, Regulatory Sequences, Nucleic Acid, Stochastic Processes, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Helper-Inducer/immunology, Thymus Gland/immunology
Pubmed
Web of science
Create date
17/01/2008 15:24
Last modification date
20/08/2019 15:56
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