A new phloroglucinol derivative from Hypericum calycinum with antifungal and in vitro antimalarial activity.
Details
Serval ID
serval:BIB_D6C028043EFE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A new phloroglucinol derivative from Hypericum calycinum with antifungal and in vitro antimalarial activity.
Journal
Planta Medica
ISSN
0032-0943 (Print)
ISSN-L
0032-0943
Publication state
Published
Issued date
1991
Volume
57
Number
6
Pages
548-551
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The new phloroglucinol derivative 1 has been isolated from the light petroleum ether extract of the aerial parts of Hypericum calycinum. Its structure has been established by means of 1H- and 13C-NMR spectroscopy and by nOe, MHQC, and HMBC experiments on its monomethyl ether derivative 3. Compound 1 was fungicidal against Cladosporium cucumerinum in a TLC bioassay. In addition, this new phloroglucinol derivative was also found to exert an interesting antimalarial activity in an in vitro test system.
Keywords
Animals, Antifungal Agents/isolation & purification, Antifungal Agents/pharmacology, Antimalarials/isolation & purification, Antimalarials/pharmacology, Biomphalaria/drug effects, Cladosporium/drug effects, Humans, Phloroglucinol/analogs & derivatives, Phloroglucinol/isolation & purification, Plants/chemistry, Plasmodium falciparum/drug effects, Tumor Cells, Cultured/drug effects
Pubmed
Web of science
Create date
25/01/2008 10:51
Last modification date
20/08/2019 15:56
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