Article: article from journal or magazin.
The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test-retest study.
all named co-authors of the QUASAR test-retest study
Alfke K., Asllani I., Bloch KM., Borogovac A., Browaeys P., Butman JA., van Cauteren M., Chai JM., Dimitrov I., Donahue MJ., Gai ND., Gatenby JC., Goode S., Hansen AE., Helle M., Higano S., Hirai T., Hoogduin H., Hoogenraad FG., Ivancevic MK., Jackson A., Jahng GH., Kampaengtip A., Kim E., Kim JH., Kim ST., Kitajima M., Knutsson L., Lackey J., Lai S., Laothamatas J., Larkman DJ., Larsson HB., Lee JH., Lee SK., Lu H., MacKay AL., Meuli RA., Moffat K., Moore EA., Morgan PS., Murata T., Mädler B., Noguchi T., Peeters R., Rollins NK., Shnier R., Sunaert S., Sundgren PC., Welch EB., Yang DM., Toshiura T., van Zijl PC. , Zimine I.
Publication types: Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Arterial Spin Labeling (ASL) is a method to measure perfusion using magnetically labeled blood water as an endogenous tracer. Being fully non-invasive, this technique is attractive for longitudinal studies of cerebral blood flow in healthy and diseased individuals, or as a surrogate marker of metabolism. So far, ASL has been restricted mostly to specialist centers due to a generally low SNR of the method and potential issues with user-dependent analysis needed to obtain quantitative measurement of cerebral blood flow (CBF). Here, we evaluated a particular implementation of ASL (called Quantitative STAR labeling of Arterial Regions or QUASAR), a method providing user independent quantification of CBF in a large test-retest study across sites from around the world, dubbed "The QUASAR reproducibility study". Altogether, 28 sites located in Asia, Europe and North America participated and a total of 284 healthy volunteers were scanned. Minimal operator dependence was assured by using an automatic planning tool and its accuracy and potential usefulness in multi-center trials was evaluated as well. Accurate repositioning between sessions was achieved with the automatic planning tool showing mean displacements of 1.87+/-0.95 mm and rotations of 1.56+/-0.66 degrees . Mean gray matter CBF was 47.4+/-7.5 [ml/100 g/min] with a between-subject standard variation SD(b)=5.5 [ml/100 g/min] and a within-subject standard deviation SD(w)=4.7 [ml/100 g/min]. The corresponding repeatability was 13.0 [ml/100 g/min] and was found to be within the range of previous studies.
Adolescent, Adult, Aged, Blood Volume/physiology, Brain Mapping, Cerebral Arteries/anatomy & histology, Cerebrovascular Circulation/physiology, Female, Humans, Male, Middle Aged, Reproducibility of Results, Software, Spin Labels, Young Adult
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