Role and organization of the actin cytoskeleton during cell-cell fusion.

Détails

ID Serval
serval:BIB_D6463F068FE7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Role and organization of the actin cytoskeleton during cell-cell fusion.
Périodique
Seminars in cell & developmental biology
Auteur(s)
Martin S.G.
ISSN
1096-3634 (Electronic)
ISSN-L
1084-9521
Statut éditorial
Publié
Date de publication
12/2016
Peer-reviewed
Oui
Volume
60
Pages
121-126
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Cell-cell fusion is a ubiquitous process that underlies fertilization and development of eukaryotes. This process requires fusogenic machineries to promote plasma membrane merging, and also relies on the organization of dedicated sub-cortical cytoskeletal assemblies. This review describes the role of actin structures, so called actin fusion foci, essential for the fusion of two distinct cell types: Drosophila myoblast cells, which fuse to form myotubes, and sexually differentiated cells of the fission yeast Schizosaccharomyces pombe, which fuse to form a zygote. I describe the respective composition and organization of the two structures, discuss their proposed role in promoting plasma membrane apposition, and consider the universality of similar structures for cell-cell fusion.

Mots-clé
Actin Cytoskeleton/metabolism, Actins/chemistry, Actins/metabolism, Animals, Cell Fusion, Humans, Myoblasts/cytology, Myoblasts/metabolism, Schizosaccharomyces/cytology, Actin fusion focus, Arp2/3, Cell fusion, Drosophila, Fertilization, Formin, Myoblast, Schizosaccharomyces pombe
Pubmed
Web of science
Création de la notice
04/08/2016 18:55
Dernière modification de la notice
03/03/2018 21:46
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