Complications of systemic juvenile idiopathic arthritis: risk factors and management recommendations.

Details

Serval ID
serval:BIB_D6430B56221B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Complications of systemic juvenile idiopathic arthritis: risk factors and management recommendations.
Journal
Expert Review of Clinical Immunology
Author(s)
Woerner A., von Scheven-Gête A., Cimaz R., Hofer M.
ISSN
1744-8409 (Electronic)
ISSN-L
1744-666X
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
11
Number
5
Pages
575-588
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish Document Type: Review
Abstract
Systemic juvenile idiopathic arthritis (SJIA) is an inflammatory condition characterized by fever, lymphadenopathy, arthritis, rash and serositis. Systemic inflammation has been associated with dysregulation of the innate immune system, suggesting that SJIA is an autoinflammatory disorder. IL-1 and IL-6 play a major role in the pathogenesis of SJIA, and treatment with IL-1 and IL-6 inhibitors has shown to be highly effective. However, complications of SJIA, including macrophage activation syndrome, limitations in functional outcome by arthritis and long-term damage from chronic inflammation, continue to be a major issue in SJIA patients' care. Translational research leading to a profound understanding of the cytokine crosstalk in SJIA and the identification of risk factors for SJIA complications will help to improve long-term outcome.
Pubmed
Web of science
Create date
18/05/2015 15:39
Last modification date
20/08/2019 15:56
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