Factors predictive of macrosomia in pregnancies with a positive oral glucose challenge test: importance of fasting plasma glucose.
Details
Serval ID
serval:BIB_D60A04805A88
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Factors predictive of macrosomia in pregnancies with a positive oral glucose challenge test: importance of fasting plasma glucose.
Journal
Diabetes & metabolism
ISSN
1878-1780 (Electronic)
ISSN-L
1262-3636
Publication state
Published
Issued date
02/2014
Peer-reviewed
Oui
Volume
40
Number
1
Pages
43-48
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
The study aimed to determine the factors associated with fetal macrosomia following a positive oral glucose challenge test (OGCT).
In this retrospective single-centre study of 1268 pregnancies with positive 50-g OGCTs (plasma glucose≥130mg/dL, or 7.2mmol/L), gestational diabetes mellitus (GDM) was defined as fasting plasma glucose (FPG)≥95mg/dL (5.3mmol/L) and/or postprandial glucose (PPG)≥120mg/dL (6.7mmol/L).
In GDM pregnancies, the odds ratios adjusted for confounders (age, BMI, ethnicity, parity and weight gain) were 2.02 for macrosomia (Z score≥1.28) and 2.62 for severe macrosomia (Z score≥1.88). For each 10-mg/dL increase in FPG, the mean birth-weight increase was 60g. Macrosomia risk did not differ between GDM patients with normal FPG (<95mg/dL, or 5.3mmol/L) and non-diabetics, but increased significantly in cases of FPG≥95mg/dL and regardless of the level of PPG.
In our study population, birth-weight and macrosomia risk were strongly correlated with FPG, suggesting that it is a simple and efficient marker for the risk of macrosomia.
In this retrospective single-centre study of 1268 pregnancies with positive 50-g OGCTs (plasma glucose≥130mg/dL, or 7.2mmol/L), gestational diabetes mellitus (GDM) was defined as fasting plasma glucose (FPG)≥95mg/dL (5.3mmol/L) and/or postprandial glucose (PPG)≥120mg/dL (6.7mmol/L).
In GDM pregnancies, the odds ratios adjusted for confounders (age, BMI, ethnicity, parity and weight gain) were 2.02 for macrosomia (Z score≥1.28) and 2.62 for severe macrosomia (Z score≥1.88). For each 10-mg/dL increase in FPG, the mean birth-weight increase was 60g. Macrosomia risk did not differ between GDM patients with normal FPG (<95mg/dL, or 5.3mmol/L) and non-diabetics, but increased significantly in cases of FPG≥95mg/dL and regardless of the level of PPG.
In our study population, birth-weight and macrosomia risk were strongly correlated with FPG, suggesting that it is a simple and efficient marker for the risk of macrosomia.
Keywords
Adult, Biomarkers/blood, Blood Glucose/metabolism, Body Mass Index, Diabetes, Gestational/blood, Diabetes, Gestational/diagnosis, Fasting, Female, Fetal Macrosomia/blood, Fetal Macrosomia/diagnosis, France, Glucose Tolerance Test, Humans, Infant, Newborn, Odds Ratio, Parity, Practice Guidelines as Topic, Predictive Value of Tests, Pregnancy, Retrospective Studies, Weight Gain, Gestational diabetes mellitus, Macrosomia, Screening
Pubmed
Web of science
Create date
13/12/2021 14:22
Last modification date
14/12/2021 7:33
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