Dendritic spine loss and synaptic alterations in Alzheimer's disease.

Détails

ID Serval
serval:BIB_D5BCBE6A8400
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Dendritic spine loss and synaptic alterations in Alzheimer's disease.
Périodique
Molecular neurobiology
Auteur(s)
Knobloch M., Mansuy I.M.
ISSN
0893-7648 (Print)
ISSN-L
0893-7648
Statut éditorial
Publié
Date de publication
02/2008
Peer-reviewed
Oui
Volume
37
Numéro
1
Pages
73-82
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Dendritic spines are tiny protrusions along dendrites, which constitute major postsynaptic sites for excitatory synaptic transmission. These spines are highly motile and can undergo remodeling even in the adult nervous system. Spine remodeling and the formation of new synapses are activity-dependent processes that provide a basis for memory formation. A loss or alteration of these structures has been described in patients with neurodegenerative disorders such as Alzheimer's disease (AD), and in mouse models for these disorders. Such alteration is thought to be responsible for cognitive deficits long before or even in the absence of neuronal loss, but the underlying mechanisms are poorly understood. This review will describe recent findings and discoveries on the loss or alteration of dendritic spines induced by the amyloid beta (Abeta) peptide in the context of AD.
Mots-clé
Alzheimer Disease/metabolism, Alzheimer Disease/pathology, Alzheimer Disease/physiopathology, Amyloid beta-Peptides/metabolism, Amyloid beta-Peptides/toxicity, Animals, Cerebral Cortex/metabolism, Cerebral Cortex/pathology, Cerebral Cortex/physiopathology, Cognition Disorders/metabolism, Cognition Disorders/pathology, Cognition Disorders/physiopathology, Cytoskeleton/metabolism, Cytoskeleton/pathology, Dendritic Spines/metabolism, Dendritic Spines/pathology, Humans, Nerve Degeneration/metabolism, Nerve Degeneration/pathology, Nerve Degeneration/physiopathology, Synapses/metabolism, Synapses/pathology, Synaptic Transmission/physiology
Pubmed
Web of science
Création de la notice
25/05/2018 9:43
Dernière modification de la notice
20/08/2019 16:55
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