Vitellogenin, juvenile hormone, insulin signaling, and queen honey bee longevity.

Détails

ID Serval
serval:BIB_D5B2A1B38A28
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Vitellogenin, juvenile hormone, insulin signaling, and queen honey bee longevity.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Corona M., Velarde R.A., Remolina S., Moran-Lauter A., Wang Y., Hughes K.A., Robinson G.E.
ISSN
0027-8424
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
104
Numéro
17
Pages
7128-7133
Langue
anglais
Résumé
In most animals, longevity is achieved at the expense of fertility, but queen honey bees do not show this tradeoff. Queens are both long-lived and fertile, whereas workers, derived from the same genome, are both relatively short-lived and normally sterile. It has been suggested, on the basis of results from workers, that vitellogenin (Vg), best known as a yolk protein synthesized in the abdominal fat body, acts as an antioxidant to promote longevity in queen bees. We explored this hypothesis, as well as related roles of insulin-IGF-1 signaling and juvenile hormone. Vg was expressed in thorax and head fat body cells in an age-dependent manner, with old queens showing much higher expression than workers. In contrast, Vg expression in worker head was much lower. Queens also were more resistant to oxidative stress than workers. These results support the hypothesis that caste-specific differences in Vg expression are involved in queen longevity. Consistent with predictions from Drosophila, old queens had lower head expression of insulin-like peptide and its putative receptors than did old workers. Juvenile hormone affected the expression of Vg and insulin-IGF-1 signaling genes in opposite directions. These results suggest that conserved and species-specific mechanisms interact to regulate queen bee longevity without sacrificing fecundity.
Mots-clé
Abdomen, Animals, Bees/cytology, Bees/drug effects, Gene Expression Regulation/drug effects, In Situ Hybridization, Insect Proteins/metabolism, Insulin/genetics, Insulin/metabolism, Insulin-Like Growth Factor I/genetics, Insulin-Like Growth Factor I/metabolism, Juvenile Hormones/metabolism, Longevity/drug effects, Longevity/physiology, Methoprene/pharmacology, Models, Biological, Organ Specificity/drug effects, Oxidative Stress/drug effects, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction/drug effects, Vitellogenins/genetics, Vitellogenins/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/03/2008 11:39
Dernière modification de la notice
20/08/2019 15:55
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