PPARs: transcriptional effectors of fatty acids and their derivatives.

Details

Serval ID
serval:BIB_D5B1E068F3A8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
PPARs: transcriptional effectors of fatty acids and their derivatives.
Journal
Cellular and Molecular Life Sciences
Author(s)
Hihi A.K., Michalik L., Wahli W.
ISSN
1420-682X[print], 1420-682X[linking]
Publication state
Published
Issued date
2002
Volume
59
Number
5
Pages
790-798
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that mediate the effects of fatty acids and their derivatives at the transcriptional level. These receptors stimulate transcription after activation by their cognate ligand and binding to the promoter of target genes. In this review, we discuss how fatty acids affect PPAR functions in the cell. We first describe the structural features of the ligand binding domains of PPARs, as defined by crystallographic analyses. We then present the ligand-binding characteristics of each of the three PPARs (alpha, beta/delta, gamma) and relate ligand activation to various cellular processes: (i) fatty acid catabolism and modulation of the inflammatory response for PPARalpha, (ii) embryo implantation, cell proliferation and apoptosis for PPARbeta, and (iii) adipocytic differentiation, monocytic differentiation and cell cycle withdrawal for PPARgamma. Finally, we present possible cross-talk between the PPAR pathway and different endocrine routes within the cell, including the thyroid hormone and retinoid pathways.
Keywords
Animals, DNA-Binding Proteins/chemistry, DNA-Binding Proteins/metabolism, Fatty Acids/metabolism, Gene Expression Regulation, Humans, Models, Biological, Models, Molecular, Nuclear Proteins/chemistry, Nuclear Proteins/metabolism, Protein Structure, Tertiary, Receptors, Cytoplasmic and Nuclear/chemistry, Receptors, Cytoplasmic and Nuclear/metabolism, Signal Transduction/physiology, Transcription Factors/chemistry, Transcription Factors/metabolism
Pubmed
Web of science
Create date
24/01/2008 15:44
Last modification date
20/08/2019 15:55
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