Hepatocellular Adenomas: Morphology and Genomics.
Details
Serval ID
serval:BIB_D56775CA58C6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Hepatocellular Adenomas: Morphology and Genomics.
Journal
Gastroenterology clinics of North America
ISSN
1558-1942 (Electronic)
ISSN-L
0889-8553
Publication state
Published
Issued date
06/2017
Peer-reviewed
Oui
Volume
46
Number
2
Pages
253-272
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Hepatocellular adenomas (HCAs) are rare benign tumors. This single entity has been split into 3 subtypes corresponding to specific mutations: HNF1α-inactivated HCA; inflammatory HCA related to different mutations, all leading to activation of STAT3 pathway; and β-catenin-activated HCA related to CTNNB1 mutations. The risk of malignant transformation depends on the level of β-catenin activation, reported mainly for exon 3, including S45. It is possible using specific immunohistochemical markers to identify the 3 different HCA subtypes and the level of β-catenin activation. Fewer than 10% of HCAs remain unclassified.
Keywords
Adenoma, Liver Cell/classification, Adenoma, Liver Cell/genetics, Adenoma, Liver Cell/pathology, Biomarkers/metabolism, Fatty Liver/pathology, Genotype, Hepatocyte Nuclear Factor 1-alpha/genetics, Humans, Liver Neoplasms/classification, Liver Neoplasms/genetics, Liver Neoplasms/pathology, Phenotype, beta Catenin/genetics, Genomics, Genoptye/phenotype, Hepatocellular adenoma classification, Hepatocellular adenomas, Malignant transformation
Pubmed
Web of science
Create date
23/05/2017 15:50
Last modification date
20/08/2019 16:55
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