Connexins protect mouse pancreatic β cells against apoptosis.

Détails

ID Serval
serval:BIB_D563A9D1CAC6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Connexins protect mouse pancreatic β cells against apoptosis.
Périodique
Journal of Clinical Investigation
Auteur(s)
Klee P., Allagnat F., Pontes H., Cederroth M., Charollais A., Caille D., Britan A., Haefliger J.A., Meda P.
ISSN
1558-8238 (Electronic)
ISSN-L
0021-9738
Statut éditorial
Publié
Date de publication
2011
Volume
121
Numéro
12
Pages
4870-4879
Langue
anglais
Résumé
Type 1 diabetes develops when most insulin-producing β cells of the pancreas are killed by an autoimmune attack. The in vivo conditions modulating the sensitivity and resistance of β cells to this attack remain largely obscure. Here, we show that connexin 36 (Cx36), a trans-membrane protein that forms gap junctions between β cells in the pancreatic islets, protects mouse β cells against both cytotoxic drugs and cytokines that prevail in the islet environment at the onset of type 1 diabetes. We documented that this protection was at least partially dependent on intercellular communication, which Cx36 and other types of connexin channels establish within pancreatic islets. We further found that proinflammatory cytokines decreased expression of Cx36 and that experimental reduction or augmentation of Cx36 levels increased or decreased β cell apoptosis, respectively. Thus, we conclude that Cx36 is central to β cell protection from toxic insults.
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/01/2012 17:28
Dernière modification de la notice
20/08/2019 16:55
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