Activity standardisation of 177Lu.
Details
Serval ID
serval:BIB_D48A7B387F26
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Activity standardisation of 177Lu.
Journal
Applied radiation and isotopes
ISSN
1872-9800 (Electronic)
ISSN-L
0969-8043
Publication state
Published
Issued date
10/2023
Peer-reviewed
Oui
Volume
200
Pages
110986
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
<sup>177</sup> Lu decays through low-energy β <sup>-</sup> - and γ-emissions in addition to conversion and Auger electrons. To support the use of this radiopharmaceutical in Switzerland, a <sup>177</sup> Lu solution was standardised using the β-γ coincidence technique, as well as the TDCR method. The solution had no <sup>177m</sup> Lu impurity. Primary coincidence measurements, with plastic scintillators for beta detection, were carried out using both analogue and digital electronics. TDCR measurements using only defocusing were also made. Monte Carlo calculations were used to compute the detection efficiency. The coincidence measurements with both analogue and digital electronics are compatible within one standard uncertainty, but they are lower than (and discrepant with) the TDCR measurements. An ampoule of this solution was submitted to the BIPM as a contribution to the Système International de Référence.
Keywords
(177)Lu, 4πβ-4πγ coincidence counting, Activity standardisation, Plastic scintillation, Tdcr, TDCR
Pubmed
Web of science
Open Access
Yes
Create date
13/09/2023 15:39
Last modification date
14/12/2023 7:24