Immunoscintigraphie avec tomographie d'émission dans les cancers de la thyroïde

Details

Serval ID
serval:BIB_D3E566048A2F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunoscintigraphie avec tomographie d'émission dans les cancers de la thyroïde
Journal
Annales de Médecine Interne
Author(s)
Parmentier C., Lumbroso J., Schlumberger M., Gardet P., Mach J.P., Berche C., Rougier P., Caillou B., Tubiana M.
ISSN
0003-410X (Print)
ISSN-L
0003-410X
Publication state
Published
Issued date
1984
Volume
135
Number
5
Pages
345-350
Language
french
Notes
[Immunoscintigraphy with emission tomography in cancers of the thyroid].
Abstract
Immunoscintigraphy (IS) consists of in vivo body structure imaging using a specific labelled antibody to an antigen concentrated in the structure under study. Technically, the image contrast is better when IS is performed with a computerized emission tomography system. High concentrations of carcinoembryonic antigen (CEA) have been reported in medullary thyroid carcinoma and thyroglobulin (Tg) is a marker for differentiated thyroid carcinoma. We used injections of 131-I labelled monoclonal antibodies to CEA and Tg to detect thyroid tumours. A feasibility trial using anti-CEA antibodies gave very encouraging results. However, only tumours larger than 10 cm3 could be detected. Contradictory results were obtained using anti-Tg antibodies but this data must be considered as preliminary. Various means of improving the method and the concept of accessibility of the antigen to the antibody in vivo are discussed. This study shows IS to be a promising experimental technique. Further studies are required to define its clinical indications before it can be advocated for routine use.
Keywords
Animals, Antibodies, Monoclonal/diagnostic use, Carcinoembryonic Antigen/immunology, Carcinoma/radionuclide imaging, Humans, Mice, Rats, Thyroglobulin/immunology, Thyroid Neoplasms/radionuclide imaging, Tomography, Emission-Computed
Pubmed
Web of science
Create date
25/04/2013 15:00
Last modification date
20/08/2019 16:53
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