New Insights into the Role of Exosomes in the Heart After Myocardial Infarction.

Details

Serval ID
serval:BIB_D3B5997B10FB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
New Insights into the Role of Exosomes in the Heart After Myocardial Infarction.
Journal
Journal of cardiovascular translational research
Author(s)
Li N., Rochette L., Wu Y., Rosenblatt-Velin N.
ISSN
1937-5395 (Electronic)
ISSN-L
1937-5387
Publication state
Published
Issued date
02/2019
Peer-reviewed
Oui
Volume
12
Number
1
Pages
18-27
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Intercellular communications play a pivotal role in several cardiac pathophysiological processes. One subtype of extracellular vesicles, so-called exosomes, became known as important intercellular communication mediators in the heart. Exosomes are lipid bilayer biological nanovesicles loaded with diverse proteins, lipids, and mRNAs/microRNAs. All major cardiac cell types can modulate recipient cellular function via the release of exosomes. After myocardial infarction (MI), exosomes, especially those secreted by different cardiac stem cells, have been shown to confer cardioprotective effects, activate regenerative signals, and participate into cardiac repair. In this review, we rapidly recall the biology of exosomes at the beginning. Then we summarize the exosomes secreted by different myocardial cells and their function in cardiac intercellular communication. At last, we discuss the role of these vesicles in cardiac repair after MI.
Keywords
Animals, Cell Communication, Cell Proliferation, Exosomes/genetics, Exosomes/metabolism, Exosomes/pathology, Exosomes/transplantation, Gene Expression Regulation, Humans, Myocardial Infarction/metabolism, Myocardial Infarction/pathology, Myocardial Infarction/physiopathology, Myocardial Infarction/surgery, Myocytes, Cardiac/metabolism, Myocytes, Cardiac/pathology, Myocytes, Cardiac/transplantation, Recovery of Function, Regeneration, Signal Transduction, Stem Cell Transplantation/methods, Stem Cells/metabolism, Stem Cells/pathology, Cardiac cells, Exosomes, Myocardial infarction, Stem cell therapy
Pubmed
Web of science
Create date
10/09/2018 14:10
Last modification date
04/01/2020 6:17
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