Levels and determinants of inflammatory biomarkers in a Swiss population-based sample (CoLaus study).

Détails

Ressource 1Télécharger: BIB_D348F0F0223A.P001.pdf (105.19 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_D348F0F0223A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Levels and determinants of inflammatory biomarkers in a Swiss population-based sample (CoLaus study).
Périodique
PloS one
Auteur(s)
Marques-Vidal P., Bochud M., Bastardot F., Lüscher T., Ferrero F., Gaspoz J.M., Paccaud F., Urwyler A., von Känel R., Hock C., Waeber G., Preisig M., Vollenweider P.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
6
Numéro
6
Pages
e21002
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
to assess the levels and determinants of interleukin (IL)-1β, IL-6, tumour necrosis factor (TNF)-α and C-reactive protein (CRP) in a healthy Caucasian population.
population sample of 2884 men and 3201 women aged 35 to 75. IL-1β, IL-6 and TNF-α were assessed by a multiplexed particle-based flow cytometric assay and CRP by an immunometric assay.
Spearman rank correlations between duplicate cytokine measurements (N = 80) ranged between 0.89 and 0.96; intra-class correlation coefficients ranged between 0.94 and 0.97, indicating good reproducibility. Among the 6085 participants, 2289 (37.6%), 451 (7.4%) and 43 (0.7%) had IL-1β, IL-6 and TNF-α levels below detection limits, respectively. Median (interquartile range) for participants with detectable values were 1.17 (0.48-3.90) pg/ml for IL-1β; 1.47 (0.71-3.53) pg/ml for IL-6; 2.89 (1.82-4.53) pg/ml for TNF-α and 1.3 (0.6-2.7) ng/ml for CRP. On multivariate analysis, greater age was the only factor inversely associated with IL-1β levels. Male sex, increased BMI and smoking were associated with greater IL-6 levels, while no relationship was found for age and leisure-time PA. Male sex, greater age, increased BMI and current smoking were associated with greater TNF-α levels, while no relationship was found with leisure-time PA. CRP levels were positively related to age, BMI and smoking, and inversely to male sex and physical activity.
Population-based levels of several cytokines were established. Increased age and BMI, and to a lesser degree sex and smoking, significantly and differentially impact cytokine levels, while leisure-time physical activity has little effect.

Mots-clé
Adult, Aged, Biomarkers/metabolism, Cytokines/metabolism, Female, Humans, Inflammation/metabolism, Male, Middle Aged, Multivariate Analysis, Reproducibility of Results, Risk Factors, Switzerland
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/06/2011 13:42
Dernière modification de la notice
20/08/2019 16:53
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