Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

Détails

ID Serval
serval:BIB_D2F48436B2D1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration
Périodique
Bone
Auteur(s)
Peter  B., Pioletti  D. P., Laib  S., Bujoli  B., Pilet  P., Janvier  P., Guicheux  J., Zambelli  P. Y., Bouler  J. M., Gauthier  O.
ISSN
8756-3282 (Print)
Statut éditorial
Publié
Date de publication
01/2005
Volume
36
Numéro
1
Pages
52-60
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
Despite total hip replacement (THR) gives generally satisfactory results, the quality of outcome in young patients is markedly decreased compared to the average THR outcome. For this population, pharmacological treatment with bisphosphonate would be beneficial to decrease the peri-implant osteolysis. However, as this population does not necessarily suffer from osteoporosis, a nonsystemic treatment would be preferable. Zoledronate was then grafted to hydroxyapatite (HA) coating of titanium implants. The implants were inserted in rat condyles with various zoledronate concentrations. A positive concentration-dependent effect was observed on the peri-implant bone density and on different histomorphometric parameters. Importantly for the outcome of the implants, the mechanical fixation was increased by the local presence of zoledronate. The obtained results open the way of an easy transformation of currently existing HA-coated implants by grafting bisphosphonate onto the coating in order to increase their service life in the patients.
Mots-clé
Animals Calcium Phosphates/*administration & dosage Diphosphonates/*administration & dosage Drug Delivery Systems Female Imidazoles/*administration & dosage Microscopy, Electron, Scanning *Osseointegration Prostheses and Implants Rats Rats, Wistar Titanium
Pubmed
Web of science
Création de la notice
28/01/2008 12:29
Dernière modification de la notice
20/08/2019 15:53
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