PET-based prognostic survival model after radiotherapy for head and neck cancer.

Détails

ID Serval
serval:BIB_D2D4701F91B6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
PET-based prognostic survival model after radiotherapy for head and neck cancer.
Périodique
European journal of nuclear medicine and molecular imaging
Auteur(s)
Castelli J., Depeursinge A., Devillers A., Campillo-Gimenez B., Dicente Y., Prior J.O., Chajon E., Jegoux F., Sire C., Acosta O., Gherga E., Sun X., De Bari B., Bourhis J., de Crevoisier R.
ISSN
1619-7089 (Electronic)
ISSN-L
1619-7070
Statut éditorial
Publié
Date de publication
03/2019
Peer-reviewed
Oui
Volume
46
Numéro
3
Pages
638-649
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The aims of this multicentre retrospective study of locally advanced head and neck cancer (LAHNC) treated with definitive radiotherapy were to (1) identify positron emission tomography (PET)- <sup>18</sup> F-fluorodeoxyglucose ( <sup>18</sup> F-FDG) parameters correlated with overall survival (OS) in a training cohort, (2) compute a prognostic model, and (3) externally validate this model in an independent cohort.
A total of 237 consecutive LAHNC patients divided into training (n = 127) and validation cohorts (n = 110) were retrospectively analysed. The following PET parameters were analysed: SUV <sub>Max</sub> , metabolic tumour volume (MTV), total lesion glycolysis (TLG), and SUV <sub>Mean</sub> for the primary tumour and lymph nodes using a relative SUV <sub>Max</sub> threshold or an absolute SUV threshold. Cox analyses were performed on OS in the training cohort. The c-index was used to identify the highly prognostic parameters. A prognostic model was subsequently identified, and a nomogram was generated. The model was externally tested in the validation cohort.
In univariate analysis, the significant PET parameters for the primary tumour included MTV (relative thresholds from 6 to 83% and absolute thresholds from 1.5 to 6.5) and TLG (relative thresholds from 1 to 82% and absolute thresholds from 0.5 to 4.5). For the lymph nodes, the significant parameters included MTV and TLG regardless of the threshold value. In multivariate analysis, tumour site, p16 status, MTV35% of the primary tumour, and MTV44% of the lymph nodes were independent predictors of OS. Based on these four parameters, a prognostic model was identified with a c-index of 0.72. The corresponding nomogram was generated. This prognostic model was externally validated, achieving a c-index of 0.66.
A prognostic model of OS based on primary tumour and lymph node MTV, tumour site, and p16 status was proposed and validated. The corresponding nomogram may be used to tailor individualized treatment.
Mots-clé
Female, Fluorodeoxyglucose F18, Head and Neck Neoplasms/diagnostic imaging, Head and Neck Neoplasms/radiotherapy, Humans, Male, Middle Aged, Positron Emission Tomography Computed Tomography, Prognosis, Proportional Hazards Models, Retrospective Studies, Head and neck cancer, Nomogram, PET, Prognostic score, Radiotherapy
Pubmed
Web of science
Création de la notice
29/08/2018 13:48
Dernière modification de la notice
20/08/2019 15:52
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