Article: article from journal or magazin.
Investigation of high-resolution functional magnetic resonance imaging by means of surface and array radiofrequency coils at 7 T.
Magnetic Resonance Imaging
Publication types: Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
In this investigation, high-resolution, 1x1x1-mm(3) functional magnetic resonance imaging (fMRI) at 7 T is performed using a multichannel array head coil and a surface coil approach. Scan geometry was optimized for each coil separately to exploit the strengths of both coils. Acquisitions with the surface coil focused on partial brain coverage, while whole-brain coverage fMRI experiments were performed with the array head coil. BOLD sensitivity in the occipital lobe was found to be higher with the surface coil than with the head array, suggesting that restriction of signal detection to the area of interest may be beneficial for localized activation studies. Performing independent component analysis (ICA) decomposition of the fMRI data, we consistently detected BOLD signal changes and resting state networks. In the surface coil data, a small negative BOLD response could be detected in these resting state network areas. Also in the data acquired with the surface coil, two distinct components of the positive BOLD signal were consistently observed. These two components were tentatively assigned to tissue and venous signal changes.
Brain/anatomy & histology, Brain/physiology, Brain Mapping/instrumentation, Brain Mapping/methods, Computer-Aided Design, Equipment Design, Equipment Failure Analysis, Evoked Potentials/physiology, Humans, Image Enhancement/instrumentation, Magnetic Resonance Imaging/instrumentation, Magnetic Resonance Imaging/methods, Magnetics/instrumentation, Radio Waves, Reproducibility of Results, Sensitivity and Specificity, Transducers
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