Perivascular medical devices and drug delivery systems: Making the right choices.

Détails

ID Serval
serval:BIB_D2B519231867
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Perivascular medical devices and drug delivery systems: Making the right choices.
Périodique
Biomaterials
Auteur(s)
Mylonaki I., Allémann É., Saucy F., Haefliger J.A., Delie F., Jordan O.
ISSN
1878-5905 (Electronic)
ISSN-L
0142-9612
Statut éditorial
Publié
Date de publication
06/2017
Peer-reviewed
Oui
Volume
128
Pages
56-68
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Perivascular medical devices and perivascular drug delivery systems are conceived for local application around a blood vessel during open vascular surgery. These systems provide mechanical support and/or pharmacological activity for the prevention of intimal hyperplasia following vessel injury. Despite abundant reports in the literature and numerous clinical trials, no efficient perivascular treatment is available. In this review, the existing perivascular medical devices and perivascular drug delivery systems, such as polymeric gels, meshes, sheaths, wraps, matrices, and metal meshes, are jointly evaluated. The key criteria for the design of an ideal perivascular system are identified. Perivascular treatments should have mechanical specifications that ensure system localization, prolonged retention and adequate vascular constriction. From the data gathered, it appears that a drug is necessary to increase the efficacy of these systems. As such, the release kinetics of pharmacological agents should match the development of the pathology. A successful perivascular system must combine these optimized pharmacological and mechanical properties to be efficient.

Mots-clé
Animals, Blood Vessels/physiology, Blood Vessels/physiopathology, Clinical Trials as Topic, Drug Delivery Systems, Drug Liberation, Equipment and Supplies, Humans, Tissue Distribution, Cuff, Intimal hyperplasia, Mesh, Periadventitial administration, Perivascular administration, Wrap
Pubmed
Web of science
Création de la notice
21/03/2017 19:08
Dernière modification de la notice
20/08/2019 16:52
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