Passive immunization with neutralizing antibodies interrupts the mouse mammary tumor virus life cycle.

Details

Serval ID
serval:BIB_D29D8D137628
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Passive immunization with neutralizing antibodies interrupts the mouse mammary tumor virus life cycle.
Journal
Journal of virology
Author(s)
Mpandi M., Otten L.A., Lavanchy C., Acha-Orbea H., Finke D.
ISSN
0022-538X
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
77
Number
17
Pages
9369-77
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Mouse mammary tumor virus (MMTV) infects the host via mucosal surfaces and exploits the host immune system for systemic spread and chronic infection. We have tested a neutralizing rat monoclonal antibody specific for the retroviral envelope glycoprotein gp52 for its efficiency in preventing acute and chronic mucosal and systemic infection. The antibody completely inhibits the superantigen response and chronic viral infection following systemic or nasal infection. Surprisingly however, the antibody only partially inhibits the early infection of antigen-presenting cells in the draining lymph node. Despite this initially inefficient protection from infection, superantigen-specific B- and T-cell responses and systemic viral spread are abolished, leading to complete clearance of the retroviral infection and hence interruption of the viral life cycle. In conclusion, systemic neutralizing monoclonal antibodies can provide an efficient protection against chronic retroviral amplification and persistence.
Keywords
Animals, Antibodies, Monoclonal, Antibodies, Viral, Antigens, Viral, Tumor, B-Lymphocytes, Base Sequence, Cell Differentiation, DNA, Viral, Female, Immunity, Mucosal, Immunization, Passive, Mammary Neoplasms, Experimental, Mammary Tumor Virus, Mouse, Mice, Mice, Inbred BALB C, Neutralization Tests, Rats, Rats, Inbred Lew, Retroviridae Infections, Tumor Virus Infections
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:47
Last modification date
20/08/2019 15:52
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