Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.

Détails

Ressource 1Télécharger: BIB_D28CB2C1FFAA.P001.pdf (8061.61 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_D28CB2C1FFAA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.
Périodique
Plos Biology
Auteur(s)
Niquille Mathieu, Garel Sonia, Mann Fanny, Hornung Jean-Pierre, Otsmane Belkacem, Chevalley Sebastien, Parras Carlos, Guillemot Francois, Gaspar Patricia, Yanagawa Yuchio, Lebrand Cecile
ISSN
1545-7885
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
7
Numéro
10
Pages
e1000230
Langue
anglais
Notes
video sur le site plos et figshare
https://dx.doi.org/10.1371/journal.pbio.1000230
Résumé
The corpus callosum (CC) is the main pathway responsible for interhemispheric communication. CC agenesis is associated with numerous human pathologies, suggesting that a range of developmental defects can result in abnormalities in this structure. Midline glial cells are known to play a role in CC development, but we here show that two transient populations of midline neurons also make major contributions to the formation of this commissure. We report that these two neuronal populations enter the CC midline prior to the arrival of callosal pioneer axons. Using a combination of mutant analysis and in vitro assays, we demonstrate that CC neurons are necessary for normal callosal axon navigation. They exert an attractive influence on callosal axons, in part via Semaphorin 3C and its receptor Neuropilin-1. By revealing a novel and essential role for these neuronal populations in the pathfinding of a major cerebral commissure, our study brings new perspectives to pathophysiological mechanisms altering CC formation.
Mots-clé
Lateral Olfactory Tract, Cajal-Retzius Cells, Corpus-Callosum, Tangential Migration, Interneuron Migration, Ganglionic Eminence, Basal Forebrain, Cerebral-Cortex, Nervous-System, Fetal-Brain
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/12/2009 15:31
Dernière modification de la notice
09/05/2019 1:39
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