Laparoscopic Roux-En-Y Gastric Bypass Improves Lipid Profile and Decreases Cardiovascular Risk: a 5-Year Longitudinal Cohort Study of 1048 Patients.

Détails

ID Serval
serval:BIB_D24916CCE1B3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Laparoscopic Roux-En-Y Gastric Bypass Improves Lipid Profile and Decreases Cardiovascular Risk: a 5-Year Longitudinal Cohort Study of 1048 Patients.
Périodique
Obesity surgery
Auteur(s)
Gero D., Favre L., Allemann P., Fournier P., Demartines N., Suter M.
ISSN
1708-0428 (Electronic)
ISSN-L
0960-8923
Statut éditorial
Publié
Date de publication
03/2018
Peer-reviewed
Oui
Volume
28
Numéro
3
Pages
805-811
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Résumé
Dyslipidemia is a known risk factor for cardiovascular (CV) events. The aim of the study was to assess lipid profiles and their impact on CV risk changes in a large patient cohort 5 years after Roux-en-Y gastric bypass (RYGB).
All patients who underwent primary RYGB for severe obesity in our two hospitals between January 1999 and December 2009 were included. The Framingham risk score was used.
One thousand and forty-eight patients were included, 791 women and 257 men. Five-year complete lipid profile was available for 77% of patients. At 5 years, mean body mass index (BMI) decreased from 45.7 ± 6 to 31 ± 5.8 kg/m <sup>2</sup> (p < 0.001), excess BMI loss (EBMIL) was 72.35 ± 22%, and total body weight loss (TWL) 31.5 ± 9%. Lipid values improved significantly. Total- and LDL-cholesterol levels dropped at 1 year from 5.4 to 4.48 mmol/L and 3.2 to 2.41 mmol/L, respectively, and slightly increased thereafter. Triglyceride levels dropped from 2 to 1.17 mmol/L at 1 year and remained unchanged. HDL levels rose continuously from 1.27 to 1.77 mmol/L at 5 years. Lipid profile improved more in patients with greater weight loss (%EBMIL ≥ 50 or %TWL ≥ 25%). Assuming that all patients were non-smokers and other baseline risk factors (hypertension, diabetes) remained unchanged at 5 years, the amelioration of the lipid profile itself yielded to a 27% reduction of CV risk (p < 0.001).
RYGB results in sustained excess weight loss and in amelioration of the lipid profile from the first to fifth postoperative year. This improvement translates into significantly lower CV risk from the first year after surgery.
Mots-clé
Adolescent, Adult, Aged, Body Mass Index, Cardiovascular Diseases/blood, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/etiology, Cardiovascular Diseases/prevention & control, Dyslipidemias/epidemiology, Dyslipidemias/etiology, Dyslipidemias/surgery, Female, Gastric Bypass/methods, Humans, Hypertension/epidemiology, Hypertension/etiology, Hypertension/surgery, Laparoscopy/methods, Lipids/blood, Longitudinal Studies, Male, Middle Aged, Obesity, Morbid/blood, Obesity, Morbid/epidemiology, Obesity, Morbid/surgery, Postoperative Period, Risk Factors, Weight Loss, Young Adult, Bariatric surgery, Cardiovascular risk, Cholesterol, Framingham risk score, Laparoscopic roux-en-Y gastric bypass, Lipid profile, Morbid obesity, Triglycérides
Pubmed
Web of science
Création de la notice
09/10/2017 13:29
Dernière modification de la notice
20/08/2019 15:52
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