A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.

Détails

ID Serval
serval:BIB_D22C195AD634
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.
Périodique
Neuron
Auteur(s)
Eliava M., Melchior M., Knobloch-Bollmann H.S., Wahis J., da Silva Gouveia M., Tang Y., Ciobanu A.C., Triana Del Rio R., Roth L.C., Althammer F., Chavant V., Goumon Y., Gruber T., Petit-Demoulière N., Busnelli M., Chini B., Tan L.L., Mitre M., Froemke R.C., Chao M.V., Giese G., Sprengel R., Kuner R., Poisbeau P., Seeburg P.H., Stoop R., Charlet A., Grinevich V.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
89
Numéro
6
Pages
1291-1304
Langue
anglais
Résumé
Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT neurons of these nuclei innervate numerous forebrain regions and release OT into the blood from the posterior pituitary. The PVN also harbors parvocellular OT cells that project to the brainstem and spinal cord, but their function has not been directly assessed. Here, we identified a subset of approximately 30 parvocellular OT neurons, with collateral projections onto magnocellular OT neurons and neurons of deep layers of the spinal cord. Evoked OT release from these OT neurons suppresses nociception and promotes analgesia in an animal model of inflammatory pain. Our findings identify a new population of OT neurons that modulates nociception in a two tier process: (1) directly by release of OT from axons onto sensory spinal cord neurons and inhibiting their activity and (2) indirectly by stimulating OT release from SON neurons into the periphery.
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/03/2016 18:17
Dernière modification de la notice
20/08/2019 15:52
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