Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.

Détails

ID Serval
serval:BIB_D1C84D2FE663
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.
Périodique
Nature medicine
Auteur(s)
Conrad C., Boyman O., Tonel G., Tun-Kyi A., Laggner U., de Fougerolles A., Kotelianski V., Gardner H., Nestle F.O.
ISSN
1078-8956
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
13
Numéro
7
Pages
836-842
Langue
anglais
Résumé
Psoriasis is a common T cell-mediated autoimmune inflammatory disease. We show that blocking the interaction of alpha1beta1 integrin (VLA-1) with collagen prevented accumulation of epidermal T cells and immunopathology of psoriasis. Alpha1beta1 integrin, a major collagen-binding surface receptor, was exclusively expressed by epidermal but not dermal T cells. Alpha1beta1-positive T cells showed characteristic surface markers of effector memory cells and contained high levels of interferon-gamma but not interleukin-4. Blockade of alpha1beta1 inhibited migration of T cells into the epidermis in a clinically relevant xenotransplantation model. This was paralleled by a complete inhibition of psoriasis development, comparable to that caused by tumor necrosis factor-alpha blockers. These results define a crucial role for alpha1beta1 in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment focusing on T cell-extracellular matrix interactions.
Mots-clé
Animals, Antibodies, Monoclonal, Epidermis, Gene Deletion, Gene Expression Regulation, Humans, Integrin alpha1beta1, Mice, Psoriasis, T-Lymphocytes, Transplantation, Heterologous
Pubmed
Web of science
Création de la notice
31/03/2009 11:50
Dernière modification de la notice
03/03/2018 21:38
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