Initial Staging of Locally Advanced Rectal Cancer and Regional Lymph Nodes: Comparison of Diffusion-Weighted MRI With 18F-FDG-PET/CT.

Détails

Ressource 1Télécharger: BIB_D1C7BBCC2191.P001.pdf (489.71 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_D1C7BBCC2191
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Initial Staging of Locally Advanced Rectal Cancer and Regional Lymph Nodes: Comparison of Diffusion-Weighted MRI With 18F-FDG-PET/CT.
Périodique
Clinical nuclear medicine
Auteur(s)
Cerny M., Dunet V., Prior J.O., Hahnloser D., Wagner A.D., Meuli R.A., Schmidt S.
ISSN
1536-0229 (Electronic)
ISSN-L
0363-9762
Statut éditorial
Publié
Date de publication
04/2016
Peer-reviewed
Oui
Volume
41
Numéro
4
Pages
289-295
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article

Résumé
The aim of the study was to compare diffusion-weighted MRI (DW-MRI) parameters with 18F-FDG PET/CT in primary locally advanced rectal cancer (LARC).
From October 2012 to September 2014, 24 patients with histologically confirmed and untreated LARC (T3-T4) prospectively underwent a pelvic 1.5-T DW-MRI (b = 0 s/mm, b = 600 s/mm2) and a whole-body 18F-FDG PET/CT, before neoadjuvant therapy. The 2 examinations were performed on the same day. Two readers measured 18F-FDG SUVmax and SUVmean of the rectal tumor and of the pathological regional lymph nodes on PET/CT and compared these with minimum and mean values of the ADC (ADCmin and ADCmean) on maps generated from DW-MRI. The diagnostic performance of ADC values in identifying pathological lymph nodes was also assessed.
Regarding tumors (n = 24), we found a significant negative correlation between SUVmean and corresponding ADCmean values (ρ = -0.61, P = 0.0017) and between ADCmin and SUVmax (ρ = -0.66, P = 0.0005). Regarding the lymph nodes (n = 63), there was a significant negative correlation between ADCmean and SUVmean values (ρ = -0.38, P = 0.0021), but not between ADCmin and SUVmax values (ρ = -0.11, P = 0.41). Neither ADCmean nor ADCmin values helped distinguish pathological from benign lymph nodes (AUC of 0.24 [confidence interval, 0.10-0.38] and 0.41 [confidence interval, 0.22-0.60], respectively).
The correlations between ADCmean and SUVmean suggest an association between tumor cellularity and metabolic activity in untreated LARC and in regional lymph nodes. However, compared with 18F-FDG PET/CT, ADC values are not reliable for identifying pathological lymph nodes.

Mots-clé
Adult, Aged, Diffusion Magnetic Resonance Imaging, Female, Fluorodeoxyglucose F18, Humans, Lymph Nodes/diagnostic imaging, Lymph Nodes/pathology, Male, Middle Aged, Multimodal Imaging, Neoplasm Staging, Positron-Emission Tomography, Radiopharmaceuticals, Rectal Neoplasms/diagnostic imaging, Rectal Neoplasms/pathology, Tomography, X-Ray Computed
Pubmed
Web of science
Création de la notice
02/02/2016 12:04
Dernière modification de la notice
03/03/2018 21:38
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