Sleep homeostasis in the rat: simulation of the time course of EEG slow-wave activity.

Details

Serval ID
serval:BIB_D1BCC446BEC8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sleep homeostasis in the rat: simulation of the time course of EEG slow-wave activity.
Journal
Neuroscience Letters
Author(s)
Franken P., Tobler I., Borbély A.A.
ISSN
0304-3940[print], 0304-3940[linking]
Publication state
Published
Issued date
09/1991
Peer-reviewed
Oui
Volume
130
Number
2
Pages
141-144
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Erratum in: Neurosci Lett 1991 Nov 11;132(2):279.
Abstract
According to the two-process model of sleep regulation, a homeostatic Process S increases during waking and declines during sleep. For humans, the time course of S has been derived from the changes in EEG slow-wave activity (SWA; spectral power density in the 0.75-4.0 Hz range) during sleep. We tested the applicability of the model to sleep in the rat. The simulation was based on the vigilance states for consecutive 8-s epochs of a 96-h experiment in 9 animals. The level of S was made to decrease in epochs of non-REM sleep (NREMS), and to increase in epochs of waking or REM sleep according to exponential functions. By optimizing the initial value and the time constants of S, a close fit between the hourly values of SWA in NREMS and of S was obtained. The biphasic time course of SWA during baseline, its enhancement in the initial recovery period after 24-h sleep deprivation, and its subsequent prolonged undershoot were present in the simulation. We conclude that sleep homeostasis as conceptualized in the two-process model may be a general property of mammalian sleep.
Keywords
Animals, Electroencephalography, Homeostasis, Male, Models, Biological, Rats/physiology, Sleep/physiology, Sleep Deprivation/physiology, Sleep Stages/physiology
Pubmed
Web of science
Create date
24/01/2008 15:31
Last modification date
20/08/2019 15:51
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