The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes.

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_D1B746A12EEE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes.
Périodique
Scientific Reports
Auteur(s)
Djenoune L., Desban L., Gomez J., Sternberg J.R., Prendergast A., Langui D., Quan F.B., Marnas H., Auer T.O., Rio J.P., Del Bene F., Bardet P.L., Wyart C.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
7
Numéro
1
Pages
719
Langue
anglais
Résumé
Chemical and mechanical cues from the cerebrospinal fluid (CSF) can affect the development and function of the central nervous system (CNS). How such cues are detected and relayed to the CNS remains elusive. Cerebrospinal fluid-contacting neurons (CSF-cNs) situated at the interface between the CSF and the CNS are ideally located to convey such information to local networks. In the spinal cord, these GABAergic neurons expressing the PKD2L1 channel extend an apical extension into the CSF and an ascending axon in the spinal cord. In zebrafish and mouse spinal CSF-cNs originate from two distinct progenitor domains characterized by distinct cascades of transcription factors. Here we ask whether these neurons with different developmental origins differentiate into cells types with different functional properties. We show in zebrafish larva that the expression of specific markers, the morphology of the apical extension and axonal projections, as well as the neuronal targets contacted by CSF-cN axons, distinguish the two CSF-cN subtypes. Altogether our study demonstrates that the developmental origins of spinal CSF-cNs give rise to two distinct functional populations of sensory neurons. This work opens novel avenues to understand how these subtypes may carry distinct functions related to development of the spinal cord, locomotion and posture.

Pubmed
Web of science
Open Access
Oui
Création de la notice
25/04/2017 16:58
Dernière modification de la notice
20/08/2019 15:51
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