Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_D194EFF94799
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk.
Périodique
Cell Metabolism
Auteur(s)
Cirulli E.T., Guo L., Leon Swisher C., Shah N., Huang L., Napier L.A., Kirkness E.F., Spector T.D., Caskey C.T., Thorens B., Venter J.C., Telenti A.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
29
Numéro
2
Pages
488-500.e2
Langue
anglais
Résumé
Obesity is a heterogeneous phenotype that is crudely measured by body mass index (BMI). There is a need for a more precise yet portable method of phenotyping and categorizing risk in large numbers of people with obesity to advance clinical care and drug development. Here, we used non-targeted metabolomics and whole-genome sequencing to identify metabolic and genetic signatures of obesity. We find that obesity results in profound perturbation of the metabolome; nearly a third of the assayed metabolites associated with changes in BMI. A metabolome signature identifies the healthy obese and lean individuals with abnormal metabolomes-these groups differ in health outcomes and underlying genetic risk. Specifically, an abnormal metabolome associated with a 2- to 5-fold increase in cardiovascular events when comparing individuals who were matched for BMI but had opposing metabolome signatures. Because metabolome profiling identifies clinically meaningful heterogeneity in obesity, this approach could help select patients for clinical trials.
Mots-clé
MC4R, health, human genetics, metabolomics, obesity, polygenic risk scores, rare variants
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/10/2018 13:42
Dernière modification de la notice
20/08/2019 16:51
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