How important is vitamin D in preventing infections?

Détails

ID Serval
serval:BIB_D180B2706656
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
How important is vitamin D in preventing infections?
Périodique
Osteoporosis International
Auteur(s)
Lang P.O., Samaras N., Samaras D., Aspinall R.
ISSN
1433-2965 (Electronic)
ISSN-L
0937-941X
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
24
Numéro
5
Pages
1537-1553
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Interaction with the immune system is one of the most recently established nonclassic effects of vitamin D (VitD). For many years, this was considered to be limited to granulomatous diseases in which synthesis of active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) or calcitriol is known to be increased. However, recent reports have supported a role for 1,25(OH)2D3 in promoting normal function of the innate and adaptive immune systems. Crucially, these effects seem to be mediated not only by the endocrine function of circulating calcitriol but also via paracrine (i.e., refers to effects to adjacent or nearby cells) and/or intracrine activity (i.e., refers to a hormone acting inside a cell) of 1,25(OH)2D3 from its precursor 25(OH)D3, the main circulating metabolite of VitD. The ability of this vitamin to influence human immune responsiveness seems to be highly dependent on the 25(OH)D3 status of individuals and may lead to aberrant response to infection or even to autoimmunity in those who are lacking VitD. The potential health significance of this has been underlined by increasing awareness of impaired status in populations across the globe. This review will examine the current understanding of how VitD status may modulate the responsiveness of the human immune system. Furthermore, we discuss how it may play a role in host resistance to common pathogens and how effective is its supplementation for treatment or prevention of infectious diseases in humans.
Mots-clé
Adaptive Immunity, Animals, Bacterial Infections/immunology, Bacterial Infections/prevention & control, Communicable Diseases/immunology, Dietary Supplements, Disease Susceptibility, Humans, Immunity, Innate, Immunologic Factors/immunology, Immunologic Factors/therapeutic use, Parasitic Diseases/immunology, Parasitic Diseases/prevention & control, Virus Diseases/immunology, Virus Diseases/prevention & control, Vitamin D/blood, Vitamin D/immunology
Pubmed
Création de la notice
15/04/2015 10:07
Dernière modification de la notice
03/03/2018 21:37
Données d'usage